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422689 Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem

The Kir2.1 Inhibitor, ML133, also referenced under CAS 185669-79-8, controls the biological activity of Kir2.1. This small molecule/inhibitor is primarily used for Cancer applications.

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Sinónimos: Inward rectifier potassium channel blocker, ML133

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Tabla espec. clave

CAS #Empirical Formula
185669-79-8C₁₉H₁₉NO

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      Description
      OverviewA cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50 = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 > 300 µM) and displays weak activity for Kir4.1 and Kir7.1 (IC50 = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.
      Catalogue Number422689
      Brand Family Calbiochem®
      SynonymsInward rectifier potassium channel blocker, ML133
      References
      ReferencesLindsley, C.W., et al. 2011. ACS Chem. Biol. 6, 845.
      Product Information
      CAS number185669-79-8
      FormWhite solid
      Hill FormulaC₁₉H₁₉NO
      Chemical formulaC₁₉H₁₉NO
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      422689-5MG 04055977187229

      Documentation

      Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      422689

      Referencias bibliográficas

      Visión general referencias
      Lindsley, C.W., et al. 2011. ACS Chem. Biol. 6, 845.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2012 JSW
      SynonymsInward rectifier potassium channel blocker, ML133
      DescriptionA cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50 = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 > 300 µM) and displays weak activity for Kir4.1 and Kir7.1 (IC50 = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number185669-79-8
      Chemical formulaC₁₉H₁₉NO
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml; clear, colorless solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLindsley, C.W., et al. 2011. ACS Chem. Biol. 6, 845.