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420298 K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem

K-252a, Nocardiopsis sp., CAS 97161-97-2, is a cell-permeable, ATP-competitive inhibitor of multiple protein kinases (Ki = 1.8, 20, 18, 25, 20, 3 nM for CaMKII, MLCK, PKA, PKC, PKG & 140 trk).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: CaM kinase II
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420298
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Replacement Information

Tabla espec. clave

CAS #Empirical Formula
97161-97-2C₂₇H₂₁N₃O₅

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
420298-100UG
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      Description
      OverviewA cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297).
      Catalogue Number420298
      Brand Family Calbiochem®
      References
      ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
      Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
      Tapley, P., et al. 1992. Oncogene 7, 371.
      Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
      Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
      Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
      Product Information
      CAS number97161-97-2
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₂₇H₂₁N₃O₅
      Chemical formulaC₂₇H₂₁N₃O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationK-252a, Nocardiopsis sp., CAS 97161-97-2, is a cell-permeable, ATP-competitive inhibitor of multiple protein kinases (Ki = 1.8, 20, 18, 25, 20, 3 nM for CaMKII, MLCK, PKA, PKC, PKG & 140 trk).
      Biological Information
      Primary TargetCaM kinase II
      Primary Target K<sub>i</sub>1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNZ0550000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      420298-100UG 04055977210910

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      420298

      Referencias bibliográficas

      Visión general referencias
      Cools, J., et al. 2004. Cancer Res. 64, 6385.
      Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
      Tapley, P., et al. 1992. Oncogene 7, 371.
      Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
      Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
      Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

      Citas

      Título
    • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-November-2009 RFH
      DescriptionA cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297).
      FormWhite solid
      CAS number97161-97-2
      RTECSNZ0550000
      Chemical formulaC₂₇H₂₁N₃O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMF or DMSO (1 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
      Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
      Tapley, P., et al. 1992. Oncogene 7, 371.
      Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
      Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
      Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
      Citation
    • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
      		•

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      Categorías

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors