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420202 JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem

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CAS #Empirical Formula
1310809-17-6C₂₇H₂₉N₃O₆

Precios y disponibilidad

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420202-5MG
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      Description
      OverviewA substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203).
      Catalogue Number420202
      Brand Family Calbiochem®
      SynonymsJHDM Inhibitor III, Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid
      References
      ReferencesLuo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.
      Product Information
      CAS number1310809-17-6
      FormOff-white powder
      Hill FormulaC₂₇H₂₉N₃O₆
      Chemical formulaC₂₇H₂₉N₃O₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      420202-5MG 04055977210767

      Documentation

      JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      420202

      Referencias bibliográficas

      Visión general referencias
      Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.

      Licencias necesarias e Información técnica

      Cargo
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2012 JSW
      SynonymsJHDM Inhibitor III, Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid
      DescriptionA substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203).
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1310809-17-6
      Chemical formulaC₂₇H₂₉N₃O₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLuo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.