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565787 InSolution™ γ-Secretase Inhibitor XIX

InSolution™ γ-Secretase Inhibitor XIX: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: (2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide

565787
  
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₃₁H₂₄F₃N₃O₃
      Description
      Overview

      This product has been discontinued.



      Please refer to our complete listing of secretase inhibitors for possible alternatives.






      A cell-permeable benzodiazepinyl-γ-hydroxybutyramide compound that acts as a highly potent γ-secretase inhibitor (IC50 = 60 pM towards Aβ40 secretion in SH-SY5Y cells overexpressing spβA4CTF).
      Catalogue Number565787
      Brand Family Calbiochem®
      Synonyms(2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide
      References
      ReferencesChurcher, I., et al. 2003. J. Med. Chem. 46, 2275.
      Product Information
      FormLiquid
      FormulationA 5 mM solution (100 µg/37 µl) in DMSO.
      Hill FormulaC₃₁H₂₄F₃N₃O₃
      Chemical formulaC₃₁H₂₄F₃N₃O₃
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      565787 0

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ γ-Secretase Inhibitor XIX Certificados de análisis

      CargoNúmero de lote
      565787

      Referencias bibliográficas

      Visión general referencias
      Churcher, I., et al. 2003. J. Med. Chem. 46, 2275.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      Synonyms(2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide
      DescriptionA cell-permeable, highly potent γ-secretase inhibitor. Reported to inhibit Aβ40 secretion in SH-SY5Y cells overexpressing spβA4CTF (IC50 = 60 pM).
      FormLiquid
      FormulationA 5 mM solution (100 µg/37 µl) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₁H₂₄F₃N₃O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesChurcher, I., et al. 2003. J. Med. Chem. 46, 2275.