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565784 InSolution™ γ-Secretase Inhibitor IX - Calbiochem

InSolution™ g-Secretase Inhibitor IX, CAS 208255-80-5, is a 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of g-secretase Inhibitor IX (DAPT; Cat. No. 565770) in DMSO.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT

Primary Target: Aβtotal
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565784
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₃H₂₆F₂N₂O₄

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
565784-10MG
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      		 Ampolla de plást. 10 mg
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      565784-5MG
      Comprobando disponibilidad...
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      Disponibilidad a confirmar Disponibilidad a confirmar
      Ingrese cantidad 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Frasco de vidrio 5 mg
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          Description
          Catalogue Number565784
          Brand Family Calbiochem®
          SynonymsN-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
          References
          ReferencesOddo, S., et al. 2004. Neuron 43, 321.
          Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
          Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
          Product Information
          ATP CompetitiveN
          FormClear colorless liquid
          FormulationA 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
          Hill FormulaC₂₃H₂₆F₂N₂O₄
          Chemical formulaC₂₃H₂₆F₂N₂O₄
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetAβtotal
          Primary Target IC<sub>50</sub>115 nM, 200 nM against Aβtotal, Aβ42, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          565784-10MG 04055977267303
          565784-5MG 04055977191806

          Documentation

          Licencias necesarias

          Título
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          InSolution™ γ-Secretase Inhibitor IX - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          InSolution™ γ-Secretase Inhibitor IX - Calbiochem Certificados de análisis

          CargoNúmero de lote
          565784

          Referencias bibliográficas

          Visión general referencias
          Oddo, S., et al. 2004. Neuron 43, 321.
          Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
          Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.

          Citas

          Título
        • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
        • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
        • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.
          		•
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-January-2013 JSW
          SynonymsN-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
          DescriptionA cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC50 = 115 nM; Aβ42 IC50 = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of a ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP695. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.
          FormClear colorless liquid
          FormulationA 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₃H₂₆F₂N₂O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage Protect from light
          +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesOddo, S., et al. 2004. Neuron 43, 321.
          Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
          Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
          Citation
        • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
        • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
        • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.
          		•