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539749 InSolution™ PTP1B Inhibitor - Calbiochem

The InSolution™ PTP1B Inhibitor controls the biological activity of PTP1B. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ PTP1B Inhibitor - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: PTP Inhibitor XXII

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539749
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₆H₁₉Br₂N₃O₇S₃

Precios y disponibilidad

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539749-2MG
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      Description
      OverviewA cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.
      Catalogue Number539749
      Brand Family Calbiochem®
      SynonymsPTP Inhibitor XXII
      References
      ReferencesWiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.
      Product Information
      FormLiquid
      FormulationA 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.
      Hill FormulaC₂₆H₁₉Br₂N₃O₇S₃
      Chemical formulaC₂₆H₁₉Br₂N₃O₇S₃
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target IC<sub>50</sub>IC50 = 4 and 8 µM for PTP1B403 and PTP1B298, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      539749-2MG 04055977194364

      Documentation

      InSolution™ PTP1B Inhibitor - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      InSolution™ PTP1B Inhibitor - Calbiochem Certificados de análisis

      CargoNúmero de lote
      539749

      Referencias bibliográficas

      Visión general referencias
      Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-November-2011 RFH
      SynonymsPTP Inhibitor XXII
      DescriptionA cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.
      FormLiquid
      FormulationA 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₆H₁₉Br₂N₃O₇S₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesWiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.