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528101 InSolution™ PI-103

InSolution™ PI-103: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: mTOR Inhibitor V, PI 3-K Inhibitor V

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528101
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₉H₁₆N₄O₃

Precios y disponibilidad

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528101-2MG
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      Description
      Catalogue Number528101
      Brand Family Calbiochem®
      SynonymsmTOR Inhibitor V, PI 3-K Inhibitor V
      References
      ReferencesRaynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
      Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
      Knight, Z.A., et al. 2006. Cell 125, 733.
      Product Information
      FormLiquid
      FormulationA 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528100) in DMSO.
      Hill FormulaC₁₉H₁₆N₄O₃
      Chemical formulaC₁₉H₁₆N₄O₃
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      528101-2MG 04055977270471

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ PI-103 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      InSolution™ PI-103 Certificados de análisis

      CargoNúmero de lote
      528101

      Referencias bibliográficas

      Visión general referencias
      Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
      Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
      Knight, Z.A., et al. 2006. Cell 125, 733.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-December-2008 JSW
      SynonymsmTOR Inhibitor V, PI 3-K Inhibitor V
      DescriptionA cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo.
      FormLiquid
      FormulationA 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528100) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₉H₁₆N₄O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesRaynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
      Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
      Knight, Z.A., et al. 2006. Cell 125, 733.