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513001 InSolution™ PD 98059 - CAS 167869-21-8 - Calbiochem

InSolution™ PD 98059, CAS 167869-21-8, is a 5 mg/ml solution in DMSO. A a cell-permeable, selective & reversible inhibitor of MAP Kinase Kinase (MEK).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: MEK Inhibitor V

Primary Target: MAP kinase kinase (MEK)
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513001
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Descripción

Tabla espec. clave

CAS #Empirical Formula
167869-21-8C₁₆H₁₃NO₃

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      Description
      Catalogue Number513001
      Brand Family Calbiochem®
      SynonymsMEK Inhibitor V
      References
      ReferencesKültz, D., et al. 1998. J. Biol. Chem. 273, 13645.
      Dudley, D.T., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 7686.
      Langlois, W.J., et al. 1995. J. Biol. Chem. 270, 25320.
      Pang, L., et al. 1995. J. Biol. Chem. 270, 13585.
      Waters, S.B., et al. 1995. J. Biol. Chem. 270, 20883.



      Selected Citations
      Lee, J., et al. 2009. Cell Stem Cell 5, 76.
      Product Information
      CAS number167869-21-8
      ATP CompetitiveN
      FormLiquid
      FormulationA 5 mg/ml solution of PD 98059 (Cat. No. 513000) in anhydrous DMSO.
      Hill FormulaC₁₆H₁₃NO₃
      Chemical formulaC₁₆H₁₃NO₃
      ReversibleY
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ PD 98059, CAS 167869-21-8, is a 5 mg/ml solution in DMSO. A a cell-permeable, selective & reversible inhibitor of MAP Kinase Kinase (MEK).
      Biological Information
      Primary TargetMAP kinase kinase (MEK)
      Primary Target IC<sub>50</sub>2 µM in completely blocking the 4-fold increase in MAP kinase activity produced by nerve growth factor in PC12 cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      513001-1ML 07790788050924