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218708 InSolution™ Casein Kinase II Inhibitor I - Calbiochem

The InSolution™ Casein Kinase II Inhibitor I controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: CK2 rat liver, human recombinant
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218708
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₆HBr₄N₃

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
218708-5MG
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      Description
      Catalogue Number218708
      Brand Family Calbiochem®
      References
      ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.
      Product Information
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.
      Hill FormulaC₆HBr₄N₃
      Chemical formulaC₆HBr₄N₃
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCK2 rat liver, human recombinant
      Primary Target IC<sub>50</sub>900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively
      PuritySingle spot by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      218708-5MG 07790788048587

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ Casein Kinase II Inhibitor I - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      InSolution™ Casein Kinase II Inhibitor I - Calbiochem Certificados de análisis

      CargoNúmero de lote
      218708

      Referencias bibliográficas

      Visión general referencias
      Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418."
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-June-2008 RFH
      DescriptionA cell-permeable, highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC50 <1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).
      FormLiquid
      FormulationA 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆HBr₄N₃
      Structure formulaStructure formula
      PuritySingle spot by TLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Carcinogenic / Teratogenic
      ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.