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208750 InSolution™ ALLN - CAS 110044-82-1 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V

Primary Target: calpain 1
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208750
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
110044-82-1C₂₀H₃₇N₃O₄

Precios y disponibilidad

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208750-5MG
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      Description
      Catalogue Number208750
      Brand Family Calbiochem®
      SynonymsCalpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V
      References
      ReferencesMilligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
      Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
      Product Information
      CAS number110044-82-1
      ATP CompetitiveN
      FormClear colorless solution
      FormulationA 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208719) in DMSO.
      Hill FormulaC₂₀H₃₇N₃O₄
      Chemical formulaC₂₀H₃₇N₃O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcalpain 1
      Primary Target K<sub>i</sub>190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Flammable
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      208750-5MG 04055977202847

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ ALLN - CAS 110044-82-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      InSolution™ ALLN - CAS 110044-82-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      208750

      Referencias bibliográficas

      Visión general referencias
      Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
      Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.

      Folleto

      Cargo
      Caspases and other Apoptosis Related Tools Brochure

      Citas

      Título
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCalpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V
      DescriptionA 10 mM solution of ALLN (Cat. No. 208719) in anhydrous DMSO. Inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IkB-α and IkB-β by the ubiquitin-proteasome complex.
      FormClear colorless solution
      FormulationA 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208719) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number110044-82-1
      Chemical formulaC₂₀H₃₇N₃O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Flammable
      ReferencesMilligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
      Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
      Citation
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
      		•