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189826 InSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem

A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Decitabine

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189826
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
2353-33-5C₈H₁₂N₄O₄

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
189826-10MG
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      Description
      OverviewA cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.
      Catalogue Number189826
      Brand Family Calbiochem®
      SynonymsDecitabine
      References
      ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
      Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
      Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
      Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
      Haaf, T. 1995. Pharmacol. Ther. 65, 19.
      Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.
      Product Information
      CAS number2353-33-5
      FormLiquid
      FormulationA 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.
      Hill FormulaC₈H₁₂N₄O₄
      Chemical formulaC₈H₁₂N₄O₄
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥ 98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      189826-10MG 04055977222050

      Documentation

      InSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      InSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      189826

      Referencias bibliográficas

      Visión general referencias
      Eggert, A., et al. 2001. Cancer Res. 61, 1314.
      Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
      Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
      Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
      Haaf, T. 1995. Pharmacol. Ther. 65, 19.
      Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.

      Licencias necesarias e Información técnica

      Cargo
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-June-2012 JSW
      SynonymsDecitabine
      DescriptionA cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.
      FormLiquid
      FormulationA 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number2353-33-5
      Chemical formulaC₈H₁₂N₄O₄
      Structure formulaStructure formula
      Purity≥ 98% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Regulatory Review
      ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
      Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
      Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
      Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
      Haaf, T. 1995. Pharmacol. Ther. 65, 19.
      Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.