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371964 HA 1004, Dihydrochloride

A cell-permeable, reversible, and ATP-competetive inhibitor of protein kinase A, CaM kinase II, myosin light chain kinase, protein kinase C.

HA 1004, Dihydrochloride: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide, 2HCl

Primary Target: Protein kinase A
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      Descripción

      Tabla espec. clave

      CAS #Empirical Formula
      92564-34-6C₁₂H₁₅N₅O₂S · 2HCl
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, reversible, and ATP-competetive inhibitor of protein kinase A (Ki = 2.3 µM), CaM kinase II (Ki = 13 µM), myosin light chain kinase (Ki = 150 µM), protein kinase C (Ki = 40 µM), and protein kinase G (Ki = 1.3 µM). An intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmonary hypertension.
      Catalogue Number371964
      Brand Family Calbiochem®
      SynonymsN-(2-Guanidinoethyl)-5-isoquinolinesulfonamide, 2HCl
      References
      ReferencesCrowley, M.R., et al. 1994. J. Cardiovasc. Pharmacol. 23, 806.
      Neveu, I., et al. 1992. Brain Res. 570, 316.
      Leahy, J.C., and Vallano, M.L. 1991. Neuroscience 44, 361.
      Kitazono, T., et al. 1989. Biochim. Biophys. Acta 1013, 152.
      Asano, T., and Hidaka, H. 1984. J. Pharmacol. Exp. Ther. 231, 141.
      Hidaka, H., et al. 1984. Biochemistry 23, 5036.
      Product Information
      CAS number92564-34-6
      ATP CompetitiveY
      FormWhite powder
      Hill FormulaC₁₂H₁₅N₅O₂S · 2HCl
      Chemical formulaC₁₂H₁₅N₅O₂S · 2HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetProtein kinase A
      Primary Target K<sub>i</sub>2.3 µM against protein kinase A
      Purity>98% by TLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Global Trade Item Number
      Número de referencia GTIN
      371964 0