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400035 Glucose Transporter Inhibitor II - Calbiochem

The Glucose Transporter Inhibitor II controls the biological activity of Glucose Transporter.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: (Z)-5-(4-Hydroxy-3-trifluoromethyl-benzylidene)-3-(4,4,4-trifluoro-2-methyl-2-(2,2,2-trifluoroethyl)-butyl)-thiazolidine-2,4-dione

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      Descripción

      Description
      Overview

      This product has been discontinued.



      A cell-permeable thiazolidinedione compound that is shown to reversibly block glucose uptake in androgen-sensitive human prostate adenocarcinoma (LNCaP) cells transfected with GLUT1 (IC50 = 2 µM). Blocks GLUT3, GLUT4, and GLUT9-mediated transport at higher concentration (IC50 ≥ 5 µM). Binds to GLUT1 at a site that is distinct from the glucose binding site. Selectively reduces proliferation (IC50 = 2.0 µM) and induces apoptosis (IC50 = 2.5 µM) in LNCaP cells without affecting normal human prostate epithelial cells and mammary epithelial cells (~ 10 µM). Shown to elicit energy restriction-associated cellular responses in LNCaP cells, such as β-TrCP facilitated protein degradation, activation of AMP-activated kinase, and endoplasmic reticulum stress.
      Catalogue Number400035
      Brand Family Calbiochem®
      Synonyms(Z)-5-(4-Hydroxy-3-trifluoromethyl-benzylidene)-3-(4,4,4-trifluoro-2-methyl-2-(2,2,2-trifluoroethyl)-butyl)-thiazolidine-2,4-dione
      References
      ReferencesWang, D-S., et al. 2012, J. Med. Chem. 55, 3827.
      Product Information
      FormWhite powder
      Hill FormulaC₁₈H₁₄F₉NO₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetglucose transporter
      Primary Target IC<sub>50</sub>2 µ
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Use only fresh DMSO.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      400035 0