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538099 GS-493 - Calbiochem

A cell-active, bioavailable, efficacious SHP2 inhibitor. Retards cancer cell mobility & invasiveness, and prevents tumor growth in a xenograft mouse model.

GS-493 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4-((2Z)-2-(1,3-bis(4-Nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-yliden)hydrazino)benzenesulfonic acid, (Z)-4-(2-(1,3-bis(4-Nitrophenyl)-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid, SHP2 Inhibitor VII

Primary Target: SHP2
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₁H₁₄N₆O₈S

Precios y disponibilidad

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      Description
      OverviewA cell-permeable, bioavailable, non-toxic p-nitro analog of PHPS1 (Cat. No. 540213) that exhibits enhanced potency and selectivity. Acts as a phosphotyrosine mimetic, substrate-competitive and reversible catalytic domain inhibitor of SHP2 (IC50 = 0.071, 2.08 & 3.17 µM for SHP2, SHP1 & PTP1B, respectively). Dose-dependently reverts HGF-stimulatd epithelial-mesenchymal transition of HPAF II cells and blocks human lung adenocarcinoma LXFA 526L anchorage-independent growth. Shown to significantly retard LXFA 526L xenografted tumor growth in mice (46 mg/kg/day, i.p., q.d.).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number538099
      Brand Family Calbiochem®
      Synonyms4-((2Z)-2-(1,3-bis(4-Nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-yliden)hydrazino)benzenesulfonic acid, (Z)-4-(2-(1,3-bis(4-Nitrophenyl)-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid, SHP2 Inhibitor VII
      DescriptionGS-493
      References
      ReferencesGrosskopf, S., et al. 2015. ChemMedChem. 10, 815.
      Product Information
      FormOrange solid
      Hill FormulaC₂₁H₁₄N₆O₈S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSHP2
      Primary Target IC<sub>50</sub>0.071, 2.08 & 3.17 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      5.38099.0001 04054839119538

      Documentation

      GS-493 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Referencias bibliográficas

      Visión general referencias
      Grosskopf, S., et al. 2015. ChemMedChem. 10, 815.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-November-2016 JSW
      Synonyms4-((2Z)-2-(1,3-bis(4-Nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-yliden)hydrazino)benzenesulfonic acid, (Z)-4-(2-(1,3-bis(4-Nitrophenyl)-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid, SHP2 Inhibitor VII
      DescriptionA cell-permeable, bioavailable, non-toxic p-nitro analog of PHPS1 (Cat. No. 540213) that exhibits enhanced potency and selectivity. Acts as a phosphotyrosine mimetic, substrate-competitive and reversible catalytic domain inhibitor of SHP2 (IC50 = 0.071, 2.08 & 3.17 µM for SHP2, SHP1 & PTP1B, respectively). Dose-dependently reverts HGF-stimulatd epithelial-mesenchymal transition of HPAF II cells and blocks human lung adenocarcinoma LXFA 526L anchorage-independent growth. Shown to significantly retard LXFA 526L xenografted tumor growth in mice (46 mg/kg/day, i.p., q.d.).
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      Purity≥98% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGrosskopf, S., et al. 2015. ChemMedChem. 10, 815.