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344960 FUT-175 - CAS 82956-11-4 - Calbiochem

A synthetic broad-specificity serine protease inhibitor.

FUT-175 - CAS 82956-11-4 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Futhan, 6-Amidino-2-naphthyl-4-guanidinobenzoate Dimethanesulfonate, Nafamostat Mesylate

Primary Target: Granzyme A
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      82956-11-4C₂₁H₂₅N₅O₈S₂
      Description
      Overview

      This product has been discontinued.



      A synthetic broad-specificity serine protease inhibitor. Potently inhibits both coagulation and complement proteinases as well as Granzyme A. Also effective toward Hageman factor and Factor Xa at submicromolar concentrations.
      Catalogue Number344960
      Brand Family Calbiochem®
      SynonymsFuthan, 6-Amidino-2-naphthyl-4-guanidinobenzoate Dimethanesulfonate, Nafamostat Mesylate
      References
      ReferencesKam, C.M., et al. 2000. Biochim. Biophys. Acta 1477, 307.
      Pfeifer, P.H., et al. 1999. Clin. Chem. 45, 1190.
      Blum, M.G., et al. 1998. Xenotransplantation 5, 35.
      Uchiba, M., et al. 1994. Thromb. Res. 74, 155.
      Inagi, R., et al. 1991. Immunol. Lett. 27, 49.
      Poe, M., et al. 1991. Arch. Biochem. Biophys. 284, 215.
      Issekutz, A.C., et al. 1990. Int. J. Immunopharmacol. 12, 1.
      Ikari, N., et al. 1983. Immunology 49, 685.
      Product Information
      CAS number82956-11-4
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₁H₂₅N₅O₈S₂
      Chemical formulaC₂₁H₂₅N₅O₈S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetGranzyme A
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDG2736000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-80°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions in H₂O are stable for up to 6 months at -80°C or up to 4 weeks at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      344960 0

      Documentation

      FUT-175 - CAS 82956-11-4 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      FUT-175 - CAS 82956-11-4 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      344960

      Referencias bibliográficas

      Visión general referencias
      Kam, C.M., et al. 2000. Biochim. Biophys. Acta 1477, 307.
      Pfeifer, P.H., et al. 1999. Clin. Chem. 45, 1190.
      Blum, M.G., et al. 1998. Xenotransplantation 5, 35.
      Uchiba, M., et al. 1994. Thromb. Res. 74, 155.
      Inagi, R., et al. 1991. Immunol. Lett. 27, 49.
      Poe, M., et al. 1991. Arch. Biochem. Biophys. 284, 215.
      Issekutz, A.C., et al. 1990. Int. J. Immunopharmacol. 12, 1.
      Ikari, N., et al. 1983. Immunology 49, 685.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-May-2008 RFH
      SynonymsFuthan, 6-Amidino-2-naphthyl-4-guanidinobenzoate Dimethanesulfonate, Nafamostat Mesylate
      DescriptionA synthetic broad-specificity serine protease inhibitor. Potently inhibits both coagulation and complement proteinases (C3a, C4a, and C5a) as well as Granzyme A. Inhibits Factor VIIa-mediated, Factor Xa generation (IC50 = 100 nM). Also effective toward Hageman factor at submicromolar concentrations.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Recommended reaction conditions50 µg/ml
      CAS number82956-11-4
      RTECSDG2736000
      Chemical formulaC₂₁H₂₅N₅O₈S₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (5 mg/ml). The use of PBS or other phosphate-containing buffers should be avoided as it may reduce solubility.
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-80°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions in H₂O are stable for up to 6 months at -80°C or up to 4 weeks at 4°C.
      Toxicity Standard Handling
      Merck USA index14, 6350
      ReferencesKam, C.M., et al. 2000. Biochim. Biophys. Acta 1477, 307.
      Pfeifer, P.H., et al. 1999. Clin. Chem. 45, 1190.
      Blum, M.G., et al. 1998. Xenotransplantation 5, 35.
      Uchiba, M., et al. 1994. Thromb. Res. 74, 155.
      Inagi, R., et al. 1991. Immunol. Lett. 27, 49.
      Poe, M., et al. 1991. Arch. Biochem. Biophys. 284, 215.
      Issekutz, A.C., et al. 1990. Int. J. Immunopharmacol. 12, 1.
      Ikari, N., et al. 1983. Immunology 49, 685.