Millipore Sigma Vibrant Logo

341310 FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem

The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403

View Products on Sigmaaldrich.com
341310
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
300657-03-8C₃₁H₂₆N₂O₃

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
341310-5MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 5 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Description
      OverviewA cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
      Catalogue Number341310
      Brand Family Calbiochem®
      Synonymsadipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
      References
      ReferencesFuruhashi, M., et al. 2007. Nature 447, 959.
      Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.
      Product Information
      CAS number300657-03-8
      FormWhite solid
      Hill FormulaC₃₁H₂₆N₂O₃
      Chemical formulaC₃₁H₂₆N₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      341310-5MG 04055977215656

      Documentation

      FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      341310

      Referencias bibliográficas

      Visión general referencias
      Furuhashi, M., et al. 2007. Nature 447, 959.
      Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-October-2008 JSW
      Synonymsadipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
      DescriptionA cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number300657-03-8
      Chemical formulaC₃₁H₂₆N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml), Methanol (50 mg/ml), or Ethanol (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesFuruhashi, M., et al. 2007. Nature 447, 959.
      Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.