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371209 Dkk-2, Mouse, Recombinant

Dkk-2, Mouse, Recombinant, consists of amino acids 26-259 and expressed in S. frugiperda 21 cells with a C-terminal His•Tag® sequence.

Dkk-2, Mouse, Recombinant: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
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371209
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Descripción

Replacement Information

Tabla espec. clave

Purity
≥95% by SDS-PAGE

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
371209-10UG
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      Description
      OverviewRecombinant, mouse Dickkopf related protein 2 (Dkk-2) consisting of amino acids 26-259 and expressed in S. frugiperda 21 cells with a C-terminal His•Tag® sequence. Dkk proteins are expressed in mesenchymal tissues and control epithelial transformations.
      Catalogue Number371209
      Brand Family Calbiochem®
      References
      ReferencesMorvan, F. et al. 2006. J. Bone Miner. Res. 21, 934.
      Mukhopadhyay, M. et al. 2006. Development 133, 2149.
      Niehrs, C. 2006. Oncogene 25, 7469.
      Li, X. et al. 2005. Nat. Genet. 37, 945.
      Bullock, C.M. et al. 2004. Mol. Pharmacol. 65, 582.
      Mao, B. and C. Niehrs 2003. Gene 302, 179.
      Brott, B. and S.Y. Sokol 2002. Mol. Cell. Biol. 22, 6100.
      Li, L. et al. 2002. J. Biol. Chem. 277, 5977.
      Mao, B. et al. 2002. Nature 417, 664.
      Mao, B. et al. 2001. Nature 411, 321.
      Wu, W. et al. 2000. Current Biol. 10,1611.
      Monaghan, A.P. et al. 1999. Mech. Dev. 87, 45.
      Krupnik, V.E. et al. 1999. Gene 238, 301.
      Product Information
      FormSolid
      FormulationLyophilized from 0.2 µm filtered PBS, BSA.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityInhibition assay:
      Inhibits WNT-3a-induced alkaline phosphatase production in MC3T3-E1 mouse osteoblastic cells in the presence of BMP-2.

      Competetive Binding Assay:
      Inhibits 50% binding of biotinylated rhDkk-1 (200 ng/ml) to immobilized rmKremen (4 µg/ml) at a concentration of 5-15 µg/ml.
      Purity≥95% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: <1.0 EU per/µg protein
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      371209-10UG 04055977213836

      Documentation

      Dkk-2, Mouse, Recombinant Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Dkk-2, Mouse, Recombinant Certificados de análisis

      CargoNúmero de lote
      371209

      Referencias bibliográficas

      Visión general referencias
      Morvan, F. et al. 2006. J. Bone Miner. Res. 21, 934.
      Mukhopadhyay, M. et al. 2006. Development 133, 2149.
      Niehrs, C. 2006. Oncogene 25, 7469.
      Li, X. et al. 2005. Nat. Genet. 37, 945.
      Bullock, C.M. et al. 2004. Mol. Pharmacol. 65, 582.
      Mao, B. and C. Niehrs 2003. Gene 302, 179.
      Brott, B. and S.Y. Sokol 2002. Mol. Cell. Biol. 22, 6100.
      Li, L. et al. 2002. J. Biol. Chem. 277, 5977.
      Mao, B. et al. 2002. Nature 417, 664.
      Mao, B. et al. 2001. Nature 411, 321.
      Wu, W. et al. 2000. Current Biol. 10,1611.
      Monaghan, A.P. et al. 1999. Mech. Dev. 87, 45.
      Krupnik, V.E. et al. 1999. Gene 238, 301.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2011 RFH
      DescriptionRecombinant, mouse Dickkopf related protein 2 (Dkk-2) consisting of amino acids 26-259 and expressed in S. frugiperda 21 cells with a C-terminal His•Tag® sequence. Dkk proteins are expressed in mesenchymal tissues and control epithelial transformations.
      FormSolid
      FormulationLyophilized from 0.2 µm filtered PBS, BSA.
      Purity≥95% by SDS-PAGE
      ContaminantsEndotoxin: <1.0 EU per/µg protein
      Biological activityInhibition assay:
      Inhibits WNT-3a-induced alkaline phosphatase production in MC3T3-E1 mouse osteoblastic cells in the presence of BMP-2.

      Competetive Binding Assay:
      Inhibits 50% binding of biotinylated rhDkk-1 (200 ng/ml) to immobilized rmKremen (4 µg/ml) at a concentration of 5-15 µg/ml.
      SolubilityReconstitute to 100 µg/ml in sterile PBS containing at least 0.1% human or bovine serum albumin.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMorvan, F. et al. 2006. J. Bone Miner. Res. 21, 934.
      Mukhopadhyay, M. et al. 2006. Development 133, 2149.
      Niehrs, C. 2006. Oncogene 25, 7469.
      Li, X. et al. 2005. Nat. Genet. 37, 945.
      Bullock, C.M. et al. 2004. Mol. Pharmacol. 65, 582.
      Mao, B. and C. Niehrs 2003. Gene 302, 179.
      Brott, B. and S.Y. Sokol 2002. Mol. Cell. Biol. 22, 6100.
      Li, L. et al. 2002. J. Biol. Chem. 277, 5977.
      Mao, B. et al. 2002. Nature 417, 664.
      Mao, B. et al. 2001. Nature 411, 321.
      Wu, W. et al. 2000. Current Biol. 10,1611.
      Monaghan, A.P. et al. 1999. Mech. Dev. 87, 45.
      Krupnik, V.E. et al. 1999. Gene 238, 301.