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239804 Cyclopamine-KAAD - Calbiochem

Cyclopamine- KAAD, CAS 306387-90-6, is a cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC₅₀ = 20 nM).

Cyclopamine-KAAD - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II

Primary Target: Hh signaling in Shh-light2 assay
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239804
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₄₄H₆₃N₃O₄

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
239804-100UG
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      239804-500UG
      Comprobando disponibilidad...
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      Disponibilidad a confirmar Disponibilidad a confirmar
      Ingrese cantidad 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Frasco de vidrio 500 μg
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          La cantidad mínima tiene que ser múltiplo de
          Maximum Quantity is
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          Ahorró ()
           
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          Description
          OverviewA potent, cell-permeable analog of Cyclopamine (Cat. No. 239803) that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Also available as a 1 mM solution in DMSO (Cat. No. 239807).
          Catalogue Number239804
          Brand Family Calbiochem®
          Synonyms3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II
          References
          ReferencesSiegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Chen, J.K., et al. 2002. Genes Dev. 16, 2743.
          Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
          Taipale, J., et al. 2000. Nature 406, 1005.
          Product Information
          ATP CompetitiveN
          FormWhite to light yellow solid
          Hill FormulaC₄₄H₆₃N₃O₄
          Chemical formulaC₄₄H₆₃N₃O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetHh signaling in Shh-light2 assay
          Primary Target IC<sub>50</sub>20 nM against Hedgehog (Hh) signaling in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells
          Purity≥70% by HPLC (sum of two isomers)
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-36/37

          Do not breathe dust.
          Wear suitable protective clothing and gloves.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          239804-100UG 04055977198881
          239804-500UG 04055977198898

          Documentation

          Licencias necesarias

          Título
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Cyclopamine-KAAD - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Cyclopamine-KAAD - Calbiochem Certificados de análisis

          CargoNúmero de lote
          239804

          Referencias bibliográficas

          Visión general referencias
          Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Chen, J.K., et al. 2002. Genes Dev. 16, 2743.
          Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
          Taipale, J., et al. 2000. Nature 406, 1005.

          Folleto

          Cargo
          Stem Cell Resource Brochure GBP

          Ficha técnica

          Cargo
          Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

          Citas

          Título
        • Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
          		•
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-October-2024 JSW
          Synonyms3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II
          DescriptionA cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis.
          FormWhite to light yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₄H₆₃N₃O₄
          Structure formulaStructure formula
          Purity≥70% by HPLC (sum of two isomers)
          SolubilityDMSO (5 mg/ml), Ethanol (1 mg/ml), or Methanol (1 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Toxicity Harmful
          ReferencesSiegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Chen, J.K., et al. 2002. Genes Dev. 16, 2743.
          Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
          Taipale, J., et al. 2000. Nature 406, 1005.
          Citation
        • Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
          		•