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342000 Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem

The Caspase Inhibitor, Negative Control, also referenced under CAS 105637-38-5, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Z-FA-FMK, Cathepsin B, Inhibitor I

Primary Target: Cathepsin-B
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      105637-38-5C₂₁H₂₃FN₂O₄
      Description
      OverviewA cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1α and IL-1β. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.
      Catalogue Number342000
      Brand Family Calbiochem®
      SynonymsZ-FA-FMK, Cathepsin B, Inhibitor I
      References
      ReferencesSchotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
      Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
      Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
      Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
      Rauber, P., et al. 1986. Biochem. J. 239, 633.
      Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
      Rasnick, D. 1985. Anal. Biochem. 149, 461.
      Product Information
      CAS number105637-38-5
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₁H₂₃FN₂O₄
      Chemical formulaC₂₁H₂₃FN₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCathepsin-B
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Phe-Ala-FMK
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      342000 0

      Documentation

      Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      342000

      Referencias bibliográficas

      Visión general referencias
      Schotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
      Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
      Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
      Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
      Rauber, P., et al. 1986. Biochem. J. 239, 633.
      Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
      Rasnick, D. 1985. Anal. Biochem. 149, 461.

      Folleto

      Cargo
      Caspases and other Apoptosis Related Tools Brochure
      Cathepsins and Related Products Technical Bulletin

      Citas

      Título
    • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      SynonymsZ-FA-FMK, Cathepsin B, Inhibitor I
      DescriptionA cell-permeable, irreversible cathepsin B inhibitor that may be potentially useful in treating arthritis. Suitable as a negative control for caspase-1 inhibition studies.
      FormOff-white solid
      CAS number105637-38-5
      Chemical formulaC₂₁H₂₃FN₂O₄
      Peptide SequenceZ-Phe-Ala-FMK
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
      Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
      Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
      Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
      Rauber, P., et al. 1986. Biochem. J. 239, 633.
      Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
      Rasnick, D. 1985. Anal. Biochem. 149, 461.
      Citation
    • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
      		•