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264155 Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem

Caspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Z-D(OMe)E(Ome)VD(OMe)-FMK

Primary Target: caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
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264155
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
210344-95-9C₃₀H₄₁FN₄O₁₂

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
264155-1MG
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      264155-250UG
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      Disponibilidad a confirmar Disponibilidad a confirmar
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      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Ampolla de plást. 250 μg
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          Description
          OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
          Catalogue Number264155
          Brand Family Calbiochem®
          SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
          References
          ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
          Nicholson, D.W. 1996. Nature Biotech. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Product Information
          CAS number210344-95-9
          ATP CompetitiveN
          FormWhite to slightly brown solid
          Hill FormulaC₃₀H₄₁FN₄O₁₂
          Chemical formulaC₃₀H₄₁FN₄O₁₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          ApplicationCaspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.
          Biological Information
          Primary Targetcaspase-3, caspase-6, caspase-7, caspase-8, caspase-10
          Purity≥90% by TLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          264155-1MG 04055977198447
          264155-250UG 04055977198454

          Documentation

          Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          264155

          Referencias bibliográficas

          Visión general referencias
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
          Nicholson, D.W. 1996. Nature Biotech. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Nicholson, D.W., et al. 1995. Nature 376, 37.

          Folleto

          Cargo
          Caspases and other Apoptosis Related Tools Brochure

          Citas

          Título
        • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
          		•
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2011 RFH
          SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
          DescriptionA potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.
          FormWhite to slightly brown solid
          CAS number210344-95-9
          Chemical formulaC₃₀H₄₁FN₄O₁₂
          Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
          Structure formulaStructure formula
          Purity≥90% by TLC
          SolubilityDMSO (5 mg/ml)
          Storage Protect from moisture
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
          Nicholson, D.W. 1996. Nature Biotech. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Citation
        • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
          		•