Millipore Sigma Vibrant Logo

218716 Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4-(3-Cyclohexyl-5-(4-fluorophenyl)-3H-imidazol-4-yl)-pyrimidin-2-ylamine, 2HCl

View Products on Sigmaaldrich.com
218716
  
Recuperando precio...
No pudo obtenerse el precio
La cantidad mínima tiene que ser múltiplo de
Maximum Quantity is
Al finalizar el pedido Más información
Ahorró ()
 
—
Solicitar precio
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

       

      Póngase en contacto con el Servicio de Atención al Cliente

      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      950912-80-8C₁₉H₂₀FN₅ • 2HCl
      Description
      Overview

      This product has been discontinued.



      A cell-permeable tri-substituted imidazole compound that acts as a potent and reversible inhibitor of casein kinase Iε/δ (IC50 = 7.7 and 14 nM, respectively) with modest to excellent selectivity over EGFR and p38 MAPK (IC50 = 150 and 190 nM, respectively) and over 43 related kinases (IC50 > 0.3 to 30 µM), and a panel containing 116-receptors, transporters and other enzymes. Shown to inhibit PER3 nuclear translocation in GFP-PER3 and CKIε-cotransfected COS7 cells (EC50 = 290 nM), and induce phase delays in circadian rhythms of monkeys & rats model (10 - 100 mg, s.c.); further, attenuate the locomotor stimulant response to methamphetamine.
      Catalogue Number218716
      Brand Family Calbiochem®
      Synonyms4-(3-Cyclohexyl-5-(4-fluorophenyl)-3H-imidazol-4-yl)-pyrimidin-2-ylamine, 2HCl
      References
      ReferencesBryant, C.D., et al. 2009. Psychopharmacology 203, 703.
      Sprouse, J., et al. 2009. Psychopharmacology 204, 735.
      Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730.
      Product Information
      CAS number950912-80-8
      FormOff-white solid
      Hill FormulaC₁₉H₂₀FN₅ • 2HCl
      Chemical formulaC₁₉H₂₀FN₅ • 2HCl
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsSoluble in DMSO (< 100 mM) or H2O ( < 100 mM); aliquot & store at -20*C; stable for 6 months. Most likely to compete with ATP.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      218716 0

      Documentation

      Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      218716

      Referencias bibliográficas

      Visión general referencias
      Bryant, C.D., et al. 2009. Psychopharmacology 203, 703.
      Sprouse, J., et al. 2009. Psychopharmacology 204, 735.
      Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730.