Millipore Sigma Vibrant Logo

208745 Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem

The Calpain Inhibitor VI, also referenced under CAS 190274-53-4, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017

Primary Target: µ-calpain
View Products on Sigmaaldrich.com
208745
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
190274-53-4C₁₇H₂₅FN₂O₄S

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
208745-1MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 1 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      208745-5MG
      Comprobando disponibilidad...
      —
      Disponibilidad a confirmar Disponibilidad a confirmar
      Ingrese cantidad 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Ampolla de plást. 5 mg
          Recuperando precio...
          No pudo obtenerse el precio
          La cantidad mínima tiene que ser múltiplo de
          Maximum Quantity is
          Al finalizar el pedido Más información
          Ahorró ()
           
          —
          Solicitar precio
          		 —
          Description
          OverviewA potent, cell-permeable, reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and L (IC50 = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured lenses.
          Catalogue Number208745
          Brand Family Calbiochem®
          SynonymsN-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
          References
          ReferencesInoue, J., et al. 2003. J. Med. Chem. 46, 868.
          Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
          Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
          Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
          Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
          Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
          Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.
          Product Information
          CAS number190274-53-4
          ATP CompetitiveN
          DeclarationSold under license of U.S. Patent 6,551,999
          FormWhite lyophilized solid
          Hill FormulaC₁₇H₂₅FN₂O₄S
          Chemical formulaC₁₇H₂₅FN₂O₄S
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetµ-calpain
          Primary Target IC<sub>50</sub>7.5 nM for µ-calpain and 78 nM for m-calpain; 15 nM and 1.6 nM against cathepsin B and L, respectively
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide Sequence4-Fluorophenylsulfonyl-Val-Leu-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          208745-1MG 04055977202816
          208745-5MG 04055977202823

          Documentation

          Licencias necesarias

          Título
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          208745

          Referencias bibliográficas

          Visión general referencias
          Inoue, J., et al. 2003. J. Med. Chem. 46, 868.
          Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
          Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
          Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
          Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
          Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
          Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

          Folleto

          Cargo
          Caspases and other Apoptosis Related Tools Brochure
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-February-2014 JSW
          SynonymsN-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
          DescriptionA cell-permeable peptide aldehyde that acts as a potent and reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and cathepsin L (IC50 = 1.6 nM). Reduces βFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation in rats. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured rat lenses.
          FormWhite lyophilized solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number190274-53-4
          Chemical formulaC₁₇H₂₅FN₂O₄S
          Peptide Sequence4-Fluorophenylsulfonyl-Val-Leu-CHO
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesInoue, J., et al. 2003. J. Med. Chem. 46, 868.
          Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
          Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
          Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
          Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
          Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
          Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.