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207000 Calcineurin Autoinhibitory Peptide - Calbiochem

The Calcineurin Autoinhibitory Peptide controls the biological activity of Mn2+-stimulated calcineurin activity. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: ITSFEEAKGLDRINERMPPRRDAMP

Primary Target: Mn2+-stimulated calcineurin activity
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₁₂₄H₂₀₅N₃₉O₃₉S₂
      Description
      OverviewSpecific calcineurin inhibitor. Corresponds to the C-terminal domain (residues 457-482) of the calmodulin-binding domain of calcineurin (PP2B). Inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 µM using 32P-myosin light chain as a substrate) but has no effect on Ni2+-stimulated enzyme activity. Does not inhibit CaM kinase II, protein phosphatase 1 or 2A.
      Catalogue Number207000
      Brand Family Calbiochem®
      SynonymsITSFEEAKGLDRINERMPPRRDAMP
      References
      ReferencesPerrino, B.A., et al. 1995. J. Biol. Chem. 270, 340.
      Yokoyama, Y., and Wang, J.H. 1994. FEBS Lett. 337, 128.
      Yokoyama, N., et al. 1993. Arch. Biochem. Biophys. 300, 615.
      Matsui, H., et al. 1991. Biochem. Int. 24, 1119.
      Hashimoto, Y., et al. 1990. J. Biol. Chem. 265, 1924.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₂₄H₂₀₅N₃₉O₃₉S₂
      Chemical formulaC₁₂₄H₂₀₅N₃₉O₃₉S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMn2+-stimulated calcineurin activity
      Primary Target IC<sub>50</sub>10 µM using 32P-myosin light chain as a substrate
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceH-Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      207000 0

      Documentation

      Calcineurin Autoinhibitory Peptide - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Calcineurin Autoinhibitory Peptide - Calbiochem Certificados de análisis

      CargoNúmero de lote
      207000

      Referencias bibliográficas

      Visión general referencias
      Perrino, B.A., et al. 1995. J. Biol. Chem. 270, 340.
      Yokoyama, Y., and Wang, J.H. 1994. FEBS Lett. 337, 128.
      Yokoyama, N., et al. 1993. Arch. Biochem. Biophys. 300, 615.
      Matsui, H., et al. 1991. Biochem. Int. 24, 1119.
      Hashimoto, Y., et al. 1990. J. Biol. Chem. 265, 1924.

      Folleto

      Cargo
      Protein Phosphatases Technical Bulletin
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-October-2008 JSW
      SynonymsITSFEEAKGLDRINERMPPRRDAMP
      DescriptionCorresponds to a C-terminal domain (residues 457-482) of the calmodulin-binding domain of calcineurin. Specific calcineurin inhibitor. Does not inhibit CaM kinase II, protein phosphatase I or 2A. Inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 µM using 32P myosin light chain as a substrate) but has no effect on Ni2+-stimulated activity.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₁₂₄H₂₀₅N₃₉O₃₉S₂
      Peptide SequenceH-Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-OH
      Purity≥97% by HPLC
      SolubilityH₂O
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesPerrino, B.A., et al. 1995. J. Biol. Chem. 270, 340.
      Yokoyama, Y., and Wang, J.H. 1994. FEBS Lett. 337, 128.
      Yokoyama, N., et al. 1993. Arch. Biochem. Biophys. 300, 615.
      Matsui, H., et al. 1991. Biochem. Int. 24, 1119.
      Hashimoto, Y., et al. 1990. J. Biol. Chem. 265, 1924.