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14-663M CaM Kinase I Protein, active, 250 µg

Active, N-terminal GST-tagged, recombinant, human CaMK1, amino acids 2-end. For use in Kinase Assays.

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14-663M
250 µg  Also available in 10 μg size (cat#14-663) and in bulk (cat#14-663-K).
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      Descripción

      Replacement Information
      Description
      Catalogue Number14-663M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionCaM Kinase I Protein, active, 250 µg
      OverviewN-terminal GST-tagged, recombinant, human CaMK1, amino acids 2-end.
      References
      Product Information
      Presentation50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 50% glycerol, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal GST-tagged, recombinant, human CaMK1, amino acids 2-end. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed in E. coli cells
      Entrez Gene Number
      Entrez Gene SummaryCalcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.
      Gene Symbol
      • CAMK1
      • CaMKI-alpha
      • MGC120318
      • CAMK1-PEN
      • CAMKI
      • CaM-KI
      • CaMKI
      • MGC120317
      Protein TargetCaMKI
      Purification MethodGlutathione-agarose
      Target Sub-FamilyCAMK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q14012 # Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes like transcriptional regulation, hormone production, translational regulation, regulation of actin filament organization and neurite outgrowth. Involved in calcium- dependent activation of the ERK pathway (By similarity). Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]- x(3)-[MVLIF]. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CTFR, MYL9, SYN1/synapsin I and SYNII/synapsin II (By similarity).
      SIZE: 370 amino acids; 41337 Da
      SUBUNIT: Monomer. Interacts with XPO1 (By similarity).
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By similarity).
      TISSUE SPECIFICITY: Ubiquitous.
      DOMAIN:SwissProt: Q14012 The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity).
      SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
      Molecular Weight68 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of ZIPtide (#12-545).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-663) and in bulk (cat#14-663-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      14-663M 04053252924637

      Documentation

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      Número de referencia Descripción  
      14-663 CaM Kinase I Protein, active, 10 µg Precios y disponibilidad

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      Categorías

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases