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236015 COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem

Descripción

Tabla espec. clave

CAS #Empirical Formula
116686-15-8C₁₅H₁₃F₂NO₄S

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236015-5MG
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      Description
      OverviewA cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.
      Catalogue Number236015
      Brand Family Calbiochem®
      Synonyms4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
      References
      ReferencesOtani, Y., et al. 2007. J. Invest. Surg. 20, 175.
      Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
      Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
      Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
      Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.
      Product Information
      CAS number116686-15-8
      FormWhite solid
      Hill FormulaC₁₅H₁₃F₂NO₄S
      Chemical formulaC₁₅H₁₃F₂NO₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥98% by HPLC
      Safety Information
      S PhraseS: 22-24/25-36/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing and eye/face protection.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      236015-5MG 04055977217155