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236012 COX-2 Inhibitor II - CAS 181696-33-3 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: SC-791, 4-[(5-Difluoromethyl-3-phenyl)-4-isoxazolyl]benzenesulfonamide

Primary Target: hCOX-2
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      181696-33-3C₁₆H₁₂F₂N₂O₃S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable isoxazolyl-benzenesulfonamide compound that acts as a potent and highly selective inhibitor of COX-2 both in vitro (IC50 = 4 nM for hCOX-2 vs. 114 µM for hCOX-1) and in vivo. Has been used extensively in various animal models to study the role of COX-2 in wound healing process.
      Catalogue Number236012
      Brand Family Calbiochem®
      SynonymsSC-791, 4-[(5-Difluoromethyl-3-phenyl)-4-isoxazolyl]benzenesulfonamide
      References
      ReferencesBlomme, E.A., et al. 2003. Br. J. Dermatol. 148, 211.
      Hardy, M.M., et al. 2003. J. Pharmacol. Exp. Ther. 304, 959.
      Product Information
      CAS number181696-33-3
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₆H₁₂F₂N₂O₃S
      Chemical formulaC₁₆H₁₂F₂N₂O₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargethCOX-2
      Primary Target IC<sub>50</sub>4 nM for hCOX-2 vs. 114 µM for hCOX-1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      236012 0

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      COX-2 Inhibitor II - CAS 181696-33-3 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      COX-2 Inhibitor II - CAS 181696-33-3 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      236012

      Referencias bibliográficas

      Visión general referencias
      Blomme, E.A., et al. 2003. Br. J. Dermatol. 148, 211.
      Hardy, M.M., et al. 2003. J. Pharmacol. Exp. Ther. 304, 959.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2011 RFH
      SynonymsSC-791, 4-[(5-Difluoromethyl-3-phenyl)-4-isoxazolyl]benzenesulfonamide
      DescriptionA cell-permeable, potent, and highly selective inhibitor of cyclooxygenase-2 (COX-2) both in vitro (IC50 = 4 nM for hCOX-2 vs. 114 µM for hCOX-1) and in vivo. Extensively used in various animal models to study the role of COX-2 in the wound healing process.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number181696-33-3
      Chemical formulaC₁₆H₁₂F₂N₂O₃S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBlomme, E.A., et al. 2003. Br. J. Dermatol. 148, 211.
      Hardy, M.M., et al. 2003. J. Pharmacol. Exp. Ther. 304, 959.