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217693 CDC25 Phosphatase Inhibitor III, BN82685, Benzoate Salt

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 5-(2-Dimethylamino-ethylamino)-2-methyl-benzothiazole-4,7-dione, benzoate

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      Descripción

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We are offering CDC25 Phosphatase Inhibitor I, BN82002 (Cat. No. 217691) and CDC25 Phosphatase Inhibitor II, NSC 663284 (Cat. No. 217692) as possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A cell-permeable dioxobenzothiazole compound that acts as a potent, selective, and irreversible inhibitor of CDC25 family phosphatases (IC50 = 109, 160, 249, 201, and 117 nM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Shown to block CDC25-dependent cellular dephosphorylation, mitosis, cell cycle progression, and proliferation in vitro and inhibit tumor growth in mice in vivo.
      Catalogue Number217693
      Brand Family Calbiochem®
      Synonyms5-(2-Dimethylamino-ethylamino)-2-methyl-benzothiazole-4,7-dione, benzoate
      References
      ReferencesCazales, M., et al. 2007. Mol. Cancer. Ther. 6, 318. Lavergne, O., et al. 2005. Bioorg. Med. Chem. Lett. 16, 171. Brezak, M.C., et al. 2005. Mol. Cancer Ther. 4, 1378.
      Product Information
      FormRed solid
      Hill FormulaC₁₂H₁₅N₃O₂S • C₇H₆O₂
      Chemical formulaC₁₂H₁₅N₃O₂S • C₇H₆O₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      217693 0

      Documentation

      CDC25 Phosphatase Inhibitor III, BN82685, Benzoate Salt Certificados de análisis

      CargoNúmero de lote
      217693

      Referencias bibliográficas

      Visión general referencias
      Cazales, M., et al. 2007. Mol. Cancer. Ther. 6, 318. Lavergne, O., et al. 2005. Bioorg. Med. Chem. Lett. 16, 171. Brezak, M.C., et al. 2005. Mol. Cancer Ther. 4, 1378.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-June-2008 RFH
      Synonyms5-(2-Dimethylamino-ethylamino)-2-methyl-benzothiazole-4,7-dione, benzoate
      DescriptionA cell-permeable dioxobenzothiazole compound that acts as a potent, selective, and irreversible inhibitor of CDC25 family phosphatases (IC50 = 109, 160, 249, 201, and 117 nM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Shown to block CDC25-dependent cellular dephosphorylation, mitosis, cell cycle progression, and proliferation in vitro and inhibit tumor growth in mice in vivo.
      FormRed solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₂H₁₅N₃O₂S • C₇H₆O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml). The use of fresh DMSO is strongly recommended for reconstitution.
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCazales, M., et al. 2007. Mol. Cancer. Ther. 6, 318. Lavergne, O., et al. 2005. Bioorg. Med. Chem. Lett. 16, 171. Brezak, M.C., et al. 2005. Mol. Cancer Ther. 4, 1378.