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SCC273 C57MG Mouse Mammary Epithelial Cell Line

C57MG mouse mammary epithelial cell line is a useful model system for studies of breast cancer malignancy.

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SCC273
≥1X10⁶ cells/vial   
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      Descripción

      Description
      Catalogue NumberSCC273
      DescriptionC57MG Mouse Mammary Epithelial Cell Line
      Background InformationCarcinomas arising from epithelial cells lining the mammary glands comprise the overwhelming majority of breast cancer cases (1). Transformation of mammary epithelial cells from their normal non-proliferative condition to an immortal state enabling hyperproliferation and malignancy occurs via bypass of senescence checkpoints. Cellular models that allow study of the mechanisms giving rise to malignancy are of paramount importance to the identification of therapeutic targets for breast cancer treatment.
      The C57MG immortalized mammary epithelial cell line is an established model for mammary epithelial malignancy. C57MG cells are syngeneic with the C57BL/6 mouse model and have demonstrated potential of transformation with many proto-oncogenic factors. The C57MG cell line is widely used in studies of the role of Wnt signaling in malignant transformation (4). C57MG cells have been shown to upregulate expression of proto-oncogenic β-catenin in response to Wnt proteins (5). The features of the C57MG cell line make it a highly relevant model system for studies of breast cancer malignancy.

      Source:
      The C57MG cell line was established from mammary epithelial tissue of a C57BL/6 mouse (2).

      References:
      1. Breast Cancer Res. 2005; 7(4): 171-179.
      2. Virology. 1978; 90(1): 12-22.
      3. Mol Cell Biol. 1992; 12(1): 321-328.
      4. BMC Dev Biol. 2004; 4: 6.
      5. Cell Growth Differ. 1997; 8(12): 1349-1358.
      Applications
      ApplicationC57MG mouse mammary epithelial cell line is a useful model system for studies of breast cancer malignancy.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Epithelial Cells
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of mouse origin and negative for inter-species contamination from rat, human, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Global Trade Item Number
      Número de referencia GTIN
      SCC273 04061841689270