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203401 Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #
      9041-93-4
      Description
      Overview

      This product has been discontinued.



      Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
      Catalogue Number203401
      Brand Family Calbiochem®
      References
      ReferencesTounekki, O., et al. 1994. Bull. Cancer 81, 1043.
      Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
      Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
      Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
      Arkin, H., et al. 1989. Cancer Res. 49, 6556.
      Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
      Takita, T., et al. 1968. Antibiotics 21, 79.
      Product Information
      CAS number9041-93-4
      FormWhite to off-white solid
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityPotency: 1.5-2.0 U/mg
      Purity≥90% by HPLC (A₂ + B₂)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEC5991990
      Safety Information
      R PhraseR: 20/21/22-36/37/38-40-42/43

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      Limited evidence of a carcinogenic effect.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      203401 0

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      203401

      Referencias bibliográficas

      Visión general referencias
      Tounekki, O., et al. 1994. Bull. Cancer 81, 1043.
      Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
      Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
      Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
      Arkin, H., et al. 1989. Cancer Res. 49, 6556.
      Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
      Takita, T., et al. 1968. Antibiotics 21, 79.

      Folleto

      Cargo
      Antibiotics Profiler
      Caspases and other Apoptosis Related Tools Brochure
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2007 JSW
      DescriptionA mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An antineoplastic agent capable of mimicking apoptosis. Useful in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
      FormWhite to off-white solid
      CAS number9041-93-4
      RTECSEC5991990
      Purity≥90% by HPLC (A₂ + B₂)
      Biological activityPotency: 1.5-2.0 U/mg
      SolubilityH₂O (20 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 1318
      ReferencesTounekki, O., et al. 1994. Bull. Cancer 81, 1043.
      Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
      Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
      Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
      Arkin, H., et al. 1989. Cancer Res. 49, 6556.
      Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
      Takita, T., et al. 1968. Antibiotics 21, 79.