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203704 BPIQ-II

203704
  
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      Descripción

      Tabla espec. clave

      CAS #Empirical Formula
      171179-32-1C₁₅H₁₀BrN₅
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM). Blocks EGF-mediated mitogenesis in Swiss/3T3 cells (IC50 = 46 nM).
      Catalogue Number203704
      Brand Family Calbiochem®
      Synonyms8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]-quinazoline
      References
      ReferencesRewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.
      Product Information
      CAS number171179-32-1
      FormPale pink solid
      Hill FormulaC₁₅H₁₀BrN₅
      Chemical formulaC₁₅H₁₀BrN₅
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>8 pM
      Secondary targetgrowth factor mediated mitogenisis in swiss 3T3 cells (Ki = 46 nM)
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      203704 0