Millipore Sigma Vibrant Logo

07-1829 Anti-phospho-NF-kB (p100) (Ser707) Antibody

View Products on Sigmaaldrich.com
07-1829
200 µL  
Recuperando precio...
No pudo obtenerse el precio
La cantidad mínima tiene que ser múltiplo de
Maximum Quantity is
Al finalizar el pedido Más información
Ahorró ()
 
Solicitar precio
Disponibilidad a confirmar
Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      Ofertas especiales

       

      Póngase en contacto con el Servicio de Atención al Cliente

      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, PIA, DBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1829
      DescriptionAnti-phospho-NF-kB (p100) (Ser707) Antibody
      Alternate Names
      • Nuclear factor NF-kappa-B p100 subunit
      • DNA-binding factor KBF2
      • H2TF1
      • Lymphocyte translocation chromosome 10 protein
      • Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
      • Oncogene Lyt-10
      • Lyt10
      • Nuclear factor NF-kappa-B p52 subunit
      Background InformationNF-kappa-B (NF-kB) is a family of ubiquitous transcription factors, which includes RelA, RelB, NF-kB1 and NF-kB2. The NF-kB family regulates multiple cellular processes, including cell growth, differentiation, inflammation, immunity, and apoptosis. In general, inactive forms of NF-kB proteins, bound by IkappaB inhibitory proteins, are present in the cytoplasm, whereas activated forms translocate to the nucleus where they exert transcriptional activity. The p100 subunit is an inactive precursor of NF-kB2, and is proteolyzed to generate the functional p52 protein and enable the formation of an active NF-kB2/p52 dimeric complex. The processing of p100 to form p52 is induced by the NF-kappaB-inducing kinase (NIK), which recruits IkappaB kinase alpha to p100, resulting in phosphorylating of p100 at serines 99, 108, 115, 123, and 872, which is required for subsequent ubiquitination and processing of p100 by the beta-TrCP ubiquitin ligase. Nuclear p100 is phosphorylated at serine 707 by GSK3, which promotes its degradation by Fbxw7α.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Phosphorylated and non-phosphorylated NF-kB peptides
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-phospho-NF-kB (p100) (Ser707) Antibody (Rabbit Polyclonal Antibody) validated in WB, PIA, DB to detect phospho-NF-kB (p100) (Ser707) also known as Nuclear factor NF-kappa-B p100 subunit or H2TF1.
      Key Applications
      • Western Blotting
      • Peptide Inhibition Assay
      • Dot Blot
      Application NotesPeptide Inhibition Analysis: A 1:500 dilution from a representative lot blocked phospho-NF-kB (p100) (Ser707) in non-starved HEK293 cell lysates.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human NF-kB (p100) phosphorylated at Ser707.
      EpitopePhosphorylated Ser707
      HostRabbit
      SpecificityThis antibody recognizes NF-kB (p100) phosphorylated at Ser707.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NFKB2
      • LYT10
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~120 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceDot Blot Specificity Analysis: Phosphorylated and non-phosphorylated NF-kB peptides (see Table) were probed with Anti-phospho-NF-kB (p100) (Ser707) (1:500 dilution).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      07-1829 04053252694646

      Documentation

      Anti-phospho-NF-kB (p100) (Ser707) Antibody Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-phospho-NF-kB (p100) (Ser707) Antibody Certificados de análisis

      CargoNúmero de lote
      Anti-phospho-NF-kB (p100) (Ser707) - 2436437 2436437
      Anti-phospho-NF-kB (p100) (Ser707) - Q2040036 Q2040036
      Anti-phospho-NF-kB (p100) (Ser707) -2544345 2544345
      Anti-phospho-NF-kB (p100) (Ser707) -2653146 2653146
      Anti-phospho-NF-kB (p100) (Ser707) -2698467 2698467
      Anti-phospho-NF-kB (p100) (Ser707) Polyclonal Antibody 3015357

      Productos y aplicaciones relacionados

      Related Products

      Número de referencia Descripción  
      AP182P Donkey Anti-Rabbit IgG Antibody, HRP conjugate, Species Adsorbed Precios y disponibilidad

      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies