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16-244 Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor® 488

Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor 488 detects level of phospho-EGFR (Tyr1173) & has been published & validated for use in FC & IC.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: EGFR, ERBB1, ERBB, mENA UniProt Number: P00533
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16-244
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MFC, ICCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue Number16-244
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor® 488
      References
      Product Information
      FormatAlexaFluor®488
      Quality LevelMQ100
      Applications
      ApplicationAnti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor 488 detects level of phospho-EGFR (Tyr1173) & has been published & validated for use in FC & IC.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide containing the Y1173 motif (...NAE[pY1173]LRV...) of the human EGFR
      Clone9H2
      HostMouse
      Specificitythe motif NAE[pY]LRV corresponding to the major autophosphorylation site of the human EGFR
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • EGFR
      • ERBB1
      • ERBB
      • mENA
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
      SIZE: 1210 amino acids; 134277 Da
      SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
      TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
      PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
      SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
      MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
      Molecular Weight175kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by positive immunostaining for phospho-EGFR in A431 cells.
      Usage Statement
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C from date of shipment
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      16-244 04053252741616

      Documentation

      Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor® 488 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor® 488 Certificados de análisis

      CargoNúmero de lote
      Anti-phospho-EGFR (Tyr1173), clone -2786967 2786967
      Anti-phospho-EGFR (Tyr1173), clone -2818271 2818271
      Anti-phospho-EGFR (Tyr1173), clone 9H2, Alexa Fluor#174; 488 Conjugate - DAM1514111 DAM1514111
      Anti-phospho-EGFR (Tyr1173), clone 9H2, Alexa Fluor#174; 488 Conjugate - DAM1557452 DAM1557452
      Anti-phospho-EGFR (Tyr1173), clone 9H2, Alexa Fluor#174; 488 conjugate - DAM1731748 DAM1731748
      Anti-phospho-EGFR (Tyr1173), clone 9H2, Alexa Fluorreg; 488 conjugate - 30510 30510
      Anti-phospho-EGFR (Tyr1173), clone 9H2, Alexa Fluorreg; 488 conjugate - 33467 33467
      Anti-phospho-EGFR (Tyr1173), clone 9H2, Alexa Fluor® 488 conjugate - 2426473 2426473
      Anti-phospho-EGFR (Tyr1173), clone 9H2, Alexa Fluor® 488 conjugate - 2301389 2301389
      Anti-phospho-EGFR (Tyr1173), clone 9H2, Alexa Fluor® 488 conjugate - 3187404 3187404
      Show more

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Cetuximab.
      Goldberg, Richard M
      Nature reviews. Drug discovery, Suppl: S10-1 (2005)  2004

      Mostrar resumen       		15962524 15962524
      Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy.
      Bianco, Roberto, et al.
      Endocr. Relat. Cancer, 12 Suppl 1: S159-71 (2005)  2004

      		16113092 16113092
      Epidermal growth factor inhibition in solid tumours.
      Ganti, Apar Kishor and Potti, Anil
      Expert opinion on biological therapy, 5: 1165-74 (2005)  2004

      Mostrar resumen       		16120047 16120047
      Structure and function of the epidermal growth factor (EGF/ErbB) family of receptors.
      Leahy, Daniel J
      Adv. Protein Chem., 68: 1-27 (2004)  2004

      		15500857 15500857

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies