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MAB4337 Anti-UTF-1 Antibody, clone 5G10.2

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MAB4337
100 µg  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MELISA, WB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB4337
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-UTF-1 Antibody, clone 5G10.2
      Background InformationUTF1 is a transcription factor that was originally identified due to its expression in Embryonic Stem (ES) cells, Embryonic Carcinoma (EC) cells, and germ line tissues. Expression was not found in adult tissues. It was thought at the time that UTF1 might play an important role in early molecular events of embryogenesis. Subsequent studies have shown that UTF1 is a target of the Oct-4 / Sox-2 complex, a key determinant of pluripotency in stem cells
      References
      Product Information
      FormatPurified
      PresentationLiquid in PBS with 0.1% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationAnti-UTF-1 Antibody, clone 5G10.2 detects level of UTF-1 & has been published & validated for use in ELISA, WB & IC.
      Key Applications
      • ELISA
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      ImmunogenRecombinant GST Fusion protein, human UTF-1
      Clone5G10.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • UTF1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q5T230 # Acts as a transcriptional coactivator of ATF2.
      SIZE: 341 amino acids; 36439 Da
      SUBUNIT: Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.
      SUBCELLULAR LOCATION: Nucleus (Probable).
      DOMAIN:SwissProt: Q5T230 The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
      PTM: Phosphorylated.
      SIMILARITY:
      Stem Cell Type
      • Human Embryonic Stem Cells
      • Mouse Embryonic Stem Cells
      • Induced Pluripotent Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MAB4337 04053252615795

      Documentation

      Anti-UTF-1 Antibody, clone 5G10.2 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-UTF-1 Antibody, clone 5G10.2 Certificados de análisis

      CargoNúmero de lote
      Human UTF-1 MONOCLONAL ANTIBODY 2916090
      Human UTF-1 MONOCLONAL ANTIBODY 3035193
      Human UTF-1 MONOCLONAL ANTIBODY - 1940963 1940963
      Human UTF-1 MONOCLONAL ANTIBODY - 1997396 1997396
      Human UTF-1 MONOCLONAL ANTIBODY - 2089412 2089412
      Human UTF-1 MONOCLONAL ANTIBODY - 2154075 2154075
      Human UTF-1 MONOCLONAL ANTIBODY - 2295667 2295667
      Human UTF-1 MONOCLONAL ANTIBODY - 3153281 3153281
      Human UTF-1 MONOCLONAL ANTIBODY - 3172457 3172457
      Human UTF-1 MONOCLONAL ANTIBODY - 3307317 3307317

      Referencias bibliográficas

      Visión general referenciasAplicación Pub Med ID
      Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach.
      Debowski, K; Warthemann, R; Lentes, J; Salinas-Riester, G; Dressel, R; Langenstroth, D; Gromoll, J; Sasaki, E; Behr, R
      PloS one  10  e0118424  2015

      Mostrar resumen
      Immunofluorescence25785453 25785453
      Expression profile of undifferentiated cell transcription factor 1 in normal and cancerous human epithelia.
      Mouallif, Mustapha, et al.
      Int J Exp Pathol, (2014)  2014

      Mostrar resumen
      24738751 24738751
      Undifferentiated embryonic cell transcription factor-1 (UTF1) inhibits the growth of cervical cancer cells by transactivating p27Kip1.
      Wu, XL; Zheng, PS
      Carcinogenesis  34  1660-8  2013

      Mostrar resumen
      23536577 23536577
      Aberrant Promoter Methylation and Expression of UTF1 during Cervical Carcinogenesis.
      Guenin, Samuel, et al.
      PLoS ONE, 7: e42704 (2012)  2011

      Mostrar resumen
      22880087 22880087
      The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells?
      Aeckerle, N; Eildermann, K; Drummer, C; Ehmcke, J; Schweyer, S; Lerchl, A; Bergmann, M; Kliesch, S; Gromoll, J; Schlatt, S; Behr, R
      Molecular human reproduction  18  477-88  2011

      Mostrar resumen
      22689537 22689537
      Expression of UTF1 in primary and metastatic testicular germ cell tumors.
      Peng Wang,Jianping Li,Robert W Allan,Charles C Guo,Yan Peng,Dengfeng Cao
      American journal of clinical pathology  134  2009

      Mostrar resumen
      20855642 20855642
      N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis.
      Tokuhara N, Namiki K, Uesugi M, Miyamoto C, Ohgoh M, Ido K, Yoshinaga T, Yamauchi T, Kuromitsu J, Kimura S, Miyamoto N, Kasuya Y
      J Biol Chem  285  33294-306. Epub 2010 Aug 18.  2009

      Mostrar resumen
      20720005 20720005
      OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres.
      Kristensen, DM; Nielsen, JE; Kalisz, M; Dalgaard, MD; Audouze, K; Larsen, ME; Jacobsen, GK; Horn, T; Brunak, S; Skakkebaek, NE; Leffers, H
      Molecular human reproduction  16  835-45  2009

      Mostrar resumen
      20123703 20123703
      Functional characterization of single-nucleotide polymorphisms in the human undifferentiated embryonic-cell transcription factor 1 gene.
      Rajkumar P Thummer,Loes J Drenth-Diephuis,Karen E Carney,Bart J L Eggen
      DNA and cell biology  29  2009

      Mostrar resumen
      20218897 20218897
      Characterization of human UTF1, a chromatin-associated protein with repressor activity expressed in pluripotent cells.
      Susanne M Kooistra,Rajkumar P Thummer,Bart J L Eggen
      Stem cell research  2  2009

      Mostrar resumen
      19393592 19393592

      Folleto

      Cargo
      Human Stem Cell Systems

      Ficha técnica

      Cargo
      Human UTF-1 MONOCLONAL ANTIBODY

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies