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ABS449 Anti-UNG1 Antibody

Anti-UNG1 Antibody is a highly specific rabbit polyclonal antibody, that targets Uracil-DNA glycosylase 1 & has been tested in western blotting & IHC.

Anti-UNG1 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: UNG, DGU, UNG1, UNG15 UniProt Number: P13051
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ABS449
100 µg  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS449
      DescriptionAnti-UNG1 Antibody
      Alternate Names
      • Uracil-DNA glycosylase 1
      • UDG1
      Background InformationUracil-DNA glycosylase 1 (UNG1), also known as UDG1, DGU or UNG15, hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, and as a result it releases free uracil. UNG1 excises uracil residues from the DNA. This event could be a result of faulty incorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Uniport describes two isoforms. The fist isoform is widely expressed with the highest expression in skeletal muscle, heart and testicles. The second isoform has the highest expression levels in tissues containing proliferating cells. Recent studies have shown that defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5). HIGM5 is a rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections.
      References
      Product Information
      FormatAffinity Purified
      Control
      • C2C12 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-UNG1 Antibody is a highly specific rabbit polyclonal antibody, that targets Uracil-DNA glycosylase 1 & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: 2 µg/mL from a representative lot detected UNG1 in human heart tissue.

      Immunofluorescence Analysis: 20 µg/mL from a representative lot detected UNG1 in human heart tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human UNG1.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the C-terminus of UNG1.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • UNG
      • DGU
      • UNG1
      • UNG15
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~37 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~34 kDa and ~35 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in C2C12 cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected UNG1 in 15 µg of C2C12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      ABS449 04053252910180

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies