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MABN641 Anti-TMEM16B Antibody, clone 7H10

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MABN641
100 µg  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HIHC, WB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN641
      DescriptionAnti-TMEM16B Antibody, clone 7H10
      Alternate Names
      • Anoctamin-2
      • Transmembrane protein 16B
      Background InformationThe protein named Anoctamin-2 or alternatively Transmembrane protein 16B and encoded by the human gene ANO2/C12orf3/TMEM16B is a calcium activated chloride channel that plays a role in smell or olfactory signal transduction and photoreception. Odorant molecules bind to odor-sensing receptors leading to an increase in calcium entry that then activates TMEM16B calcium current which amplifies the depolarization of the Odor-sensing receptors. TEMEM16B also mediates light perception amplification in the retina where TMEM16B is a component of the presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. TEMEM16B is expressed in sensory neurons particularly in the retina and olfactory neurons; it localizes to the plasma membrane where it is a multi-pass membrane bound protein. TEMEM16B has multiple isoforms and recent research suggest that the native channel may be composed of two or more splicing isoforms acting as subunits that together shape the channel properties.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TMEM16B Antibody, clone 7H10 is a highly specific mouse monoclonal antibody, that targets TMEM16B & has been tested in IHC, western blotting & ICC.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blotting Analysis: A representative lot detected TMEM16B in 293-EBNA cell lysates overexpressing TMEM16B and in mouse retina and brain homogenates (Stohr, H., et al. (2009). The Journal of Neuro. 29(21):6809-6818).
      Immunocytochemistry Analysis: A representative lot detected TMEM16B in mouse retina cells (Stohr, H., et al. (2009). The Journal of Neuro. 29(21):6809-6818).
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the N-terminus of human TMEM16B.
      EpitopeN-terminus
      Clone7H10
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ANO2
      • C12orf3
      • TMEM16B
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight114 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in mouse retina tissue.

      Imunnohistochemistry Analysis: A 1:50 dilution of this antibody detected TMEM16B in mouse retina tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABN641 04053252934964

      Documentation

      Anti-TMEM16B Antibody, clone 7H10 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-TMEM16B Antibody, clone 7H10 Certificados de análisis

      CargoNúmero de lote
      Anti-TMEM16B, clone 7H10 - 3495632 3495632
      Anti-TMEM16B, clone 7H10 - 3757195 3757195
      Anti-TMEM16B, clone 7H10 - Q2303823 Q2303823

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.
      Stöhr, Heidi, et al.
      J. Neurosci., 29: 6809-18 (2009)  2009

      Mostrar resumen
      19474308 19474308

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      New Products Flyer- Feb 2014 - Vol 1

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies