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AB770 Anti-TIMP-1 Antibody

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AB770
100 µg  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Eq, Ft, R, Rb, ShELISA, WB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB770
      Replaces04-1133
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-TIMP-1 Antibody
      Alternate Names
      • Tissue Inhibitor of Metalloproteinase-1
      References
      Product Information
      FormatAffinity Purified
      HS Code3002 15 90
      PresentationPurified immunoglobulin. Liquid in PBS containing 0.02% azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TIMP-1 Antibody detects level of TIMP-1 & has been published & validated for use in ELISA, WB, IH.
      Key Applications
      • ELISA
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting at 5-10 μg/mL: recognizes a band of approximately 28-30kDa in reduced samples.

      Immunohistochemistry: frozen and 4%PFA fixed paraffin sections: 5-20μg/mL enzymatic detection.



      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenFull length purified human fibroblast tissue inhibitor of metalloproteinases {Clark, IM (1991) Matrix 11:76-85}.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityReacts with TIMP1. Does not react with any other human proteins tested so far. The antibody reacts with native and denatured TIMP1 and TIMP1 in and out of enzyme/inhibitor complex.
      Species Reactivity
      • Bovine
      • Horse
      • Ferret
      • Rat
      • Rabbit
      • Sheep
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
      Gene Symbol
      • TIMP1
      • TIMP
      • FLJ90373
      • CLGI
      • EPA
      • EPO
      • TIMP-1
      • HCI
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01033 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
      SIZE: 207 amino acids; 23171 Da
      SUBCELLULAR LOCATION: Secreted.
      PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds.
      SIMILARITY: SwissProt: P01033 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C for up to three months from date of receipt. For extended storage, freeze in convenient undiluted aliquots at -20°C for up to twelve months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      AB770 08436037124501

      Documentation

      Anti-TIMP-1 Antibody Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-TIMP-1 Antibody Certificados de análisis

      CargoNúmero de lote
      RABBIT ANTI-HUMAN TIMP-1 POLYCLONAL ANTIBODY - 2151835 2151835
      RABBIT ANTI-HUMAN TIMP-1 POLYCLONAL ANTIBODY - 2436304 2436304
      RABBIT ANTI-HUMAN TIMP-1 - 2488812 2488812
      RABBIT ANTI-HUMAN TIMP-1 - 3245658 3245658
      RABBIT ANTI-HUMAN TIMP-1 - 3455142 3455142
      RABBIT ANTI-HUMAN TIMP-1 - 3488541 3488541
      RABBIT ANTI-HUMAN TIMP-1 - 3598062 3598062
      RABBIT ANTI-HUMAN TIMP-1 - 3770312 3770312
      RABBIT ANTI-HUMAN TIMP-1 - 3942747 3942747
      RABBIT ANTI-HUMAN TIMP-1 -2714558 2714558

      Referencias bibliográficas

      Visión general referenciasAplicación EspeciePub Med ID
      Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk.
      Huyard, F; Yzydorczyk, C; Castro, MM; Cloutier, A; Bertagnolli, M; Sartelet, H; Germain, N; Comte, B; Schulz, R; DeBlois, D; Nuyt, AM
      PloS one  9  e92287  2014

      Mostrar resumen
      ImmunohistochemistryRat24743169 24743169
      Blockade of the MEK/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model.
      Maddahi, A; Ansar, S; Chen, Q; Edvinsson, L
      Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism  31  144-54  2010

      Mostrar resumen
      20424636 20424636
      Changes in the expression of MMP-3, MMP-9, TIMP-1 and aggrecan in the condylar cartilage of rats induced by experimentally created disordered occlusion.
      Guo-Wei Wang,Mei-Qing Wang,Xiao-Jing Wang,Shi-Bin Yu,Xiao-Dong Liu,Kai Jiao
      Archives of oral biology  55  2009

      Mostrar resumen
      20728870 20728870
      MMP-9 overexpression improves myogenic cell migration and engraftment.
      Morgan J, Rouche A, Bausero P, Houssaïni A, Gross J, Fiszman MY, Alameddine HS
      Muscle Nerve  42  584-95.  2009

      Mostrar resumen
      20734311 20734311
      Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease.
      Kim J, Moody JP, Edgerly CK, Bordiuk OL, Cormier K, Smith K, Beal MF, Ferrante RJ
      Hum Mol Genet  2009

      Mostrar resumen
      20660112 20660112
      Long-term localized high-frequency electric stimulation within the myocardial infarct: effects on matrix metalloproteinases and regional remodeling.
      Rupak Mukherjee,William T Rivers,Jean Marie Ruddy,Robert G Matthews,Christine N Koval,Rebecca A Plyler,Eileen I Chang,Risha K Patel,Christine B Kern,Robert E Stroud,Francis G Spinale
      Circulation  122  2009

      Mostrar resumen Artículo Texto completo
      20566951 20566951
      Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation.
      John R Barbour, Robert E Stroud, Abigail S Lowry, Leslie L Clark, Allyson M Leone, Jeffery A Jones, Francis G Spinale, John S Ikonomidis
      The Journal of thoracic and cardiovascular surgery  132  788-95  2005

      Mostrar resumen
      17000289 17000289
      Glucose-induced changes in integrins and matrix-related functions in cultured human glomerular epithelial cells.
      Kitsiou, Paraskevi V, et al.
      Am. J. Physiol. Renal Physiol., 284: F671-9 (2003)  2003

      Mostrar resumen
      12620921 12620921
      Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy.
      Sally E Thomson,Susan V McLennan,Paul D Kirwan,Scott J Heffernan,Annemarie Hennessy,Dennis K Yue,Stephen M Twigg
      Journal of diabetes and its complications  22  2001

      Mostrar resumen
      18413184 18413184
      Overexpression of copper and zinc superoxide dismutase in transgenic mice prevents the induction and activation of matrix metalloproteinases after cold injury-induced brain trauma.
      Morita-Fujimura, Y; Fujimura, M; Gasche, Y; Copin, JC; Chan, PH
      Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism  20  130-8  1999

      Mostrar resumen
      10616801 10616801

      Ficha técnica

      Cargo
      RABBIT ANTI-HUMAN TIMP-1

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies