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MABF1214-I Anti-TCL1A Antibody, clone TCL1A

This Anti-TCL1A Antibody, clone TCL1A is validated for use in Western Blotting, Immunocytochemistry for the detection of TCL1A.

Anti-TCL1A Antibody, clone TCL1A : Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: TCL1A, TCL1 UniProt Number: P56279
MABF1214-I
100 μg  
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      Descripción

      Replacement Information
      Replacement InformationMABF1214-I is the purified version of 05-954 which is also suitable also for Immunohistochemistry application. Alexa 488 conjugated version of this product is also available under MABF1214-AF488.

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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF1214-I
      DescriptionAnti-TCL1A Antibody, clone TCL1A
      Alternate Names
      • T-cell leukemia/lymphoma protein 1A
      • TCL1A
      • Oncogene TCL-1
      • Oncogene TCL1
      • Protein p14 TCL1
      Background InformationT-cell leukemia/lymphoma protein 1A (UniProt P56279; also known as Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1, T-cell lymphoma-1) is encoded by the TCL1A (also known as TCL1) gene (Gene ID 8115) in human. TCL1A belongs to the T-cell leukemia/lymphoma 1 (TCL1) family of oncoproteins that enhance cell proliferation and survival by augmenting AKT signal transduction. TCL1A and the related TCL1B play key roles in several B and T cell malignancies. TCL1A does not exhibit enzymatic activity and functions as an AKT activity enhancer via binding to its pleckstrin homology (PH) domain, resulting in enhanced phosphorylation of downstream AKT substrates, such as glycogen synthase kinase-3 beta (GSK3beta). TCL1A is also reported to interact with IkappaB, albeit as a ~100-fold lower affinity than NF-kappaB.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-TCL1A Antibody, clone TCL1A is validated for use in Western Blotting, Immunocytochemistry for the detection of TCL1A.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:200 dilution from a representative lot detected TCL1A in HUVECs.
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 60-73 (RPMTPTQIGPSLLP) of human TCL1A.
      Epitopea.a. 60-73
      CloneTCL1A
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityTCL1A, no cross-reactivity with TML1 (TCL1B) or MTCP1.
      IsotypeIgG
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Non-Human Primate based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TCL1A
      • TCL1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~13 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Raji cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected TCL1A in 10 µg of Raji cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABF1214-I 04055977298321

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies