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MABS1704 Anti-Potassium Channel Kir6.2 Antibody, clone 10C1.1

This Anti-Potassium Channel Kir6.2 Antibody, clone 10C1.1 is validated for use in Western Blotting for the detection of Potassium Channel Kir6.2.

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Research Category: Signaling Research Sub-Category: Ion Channels & Transporters Gene Symbol: KCNJ11, BIR, HHF2, MODY13, PNDM, TNDM3 UniProt Number: Q14654
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MABS1704
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1704
      DescriptionAnti-Potassium Channel Kir6.2 Antibody, clone 10C1.1
      Alternate Names
      • ATP-sensitive inward rectifier potassium channel 11
      • IKATP
      • Inward rectifier K(+) channel Kir6.2
      • Potassium channel, inwardly rectifying subfamily J member 11
      Background InformationATP-sensitive inward rectifier potassium channel 11 (UniProt Q14654; also known as IKATP, Inward rectifier K(+) channel Kir6.2, Potassium channel, inwardly rectifying subfamily J member 11) is encoded by the KCNJ11 (also known as BIR, HHF2, MODY13, PNDM, TNDM3) gene (Gene ID 3767) in human. Inward rectifier K+ channels (Kirs) modulate cell membrane potential and are classified as K+ transport channels (Kir1.x, Kir4.x, Kir5.x, Kir7.x), classic Kir (Kir2.x), G-protein-gated Kirs (Kir2.x and Kir3.x), and ATP-sensitive Kirs (Kir6.x). Kirs mediate diverse physiological functions of both excitable and nonexcitable epithelial cells, such as cell adhesion-migration, volume regulation, apoptosis, and proliferation. ATP-sensitive potassium (K-ATP) channels are hetero-octamers composed of pore-forming Kir6.x (6.1 or 6.2) subunits and sulfonylurea receptor (SUR1 or SUR2) regulatory subunits. K-ATP channels are regulated by intracellular ATP and ADP concentrations and are highly expressed in cardiomyocytes, where they play crucial roles in ischemic preconditioning (IPC). Potassium channel openers mimic the cardioprotection, while K-ATP channel blocker or Kir6.2-knockout is shown to abolish the effect of IPC in mice. Human Kir6.2 is a 390-amino acid multi-pass membrane (a.a. 69-93, 117-128, 145-166) protein that contains two small extraceullar regions (a.a. 94-116 and 136-144) and a pore-forming domain (a.a. 117-128), having both its N- and C-terminal exposed intracellularly (a.a. 1-68 and a.a. 167-390).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Potassium Channel Kir6.2 Antibody, clone 10C1.1 is validated for use in Western Blotting for the detection of Potassium Channel Kir6.2.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A 1:1000 dilution from a representative lot detected potassium channel Kir6.2 in 10 µg of rat pancreas tissue lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding an N-terminal cytoplasmic domain sequence of human potassium channel Kir6.2.
      EpitopeN-terminal cytoplasmic domain.
      Clone10C1.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 10C1.1 targets human Kir6.2 N-terminal cytoplasmic region not present in the alternatively spliced isoform 2.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteHuman, Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KCNJ11
      • BIR
      • HHF2
      • MODY13
      • PNDM
      • TNDM3
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~45 kDa observed. 43.54 kDa (human) and 43.61 kDa (rat) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human pancreas tissue lysate.

      Western Blotting Analysis: A 1:1000 dilution of this antibody detected potassium channel Kir6.2 in 10 µg of human pancreas tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABS1704 04055977355475

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies