Millipore Sigma Vibrant Logo

ABS517 Anti-PRMT8 Antibody

This Anti-PRMT8 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of PRMT8.

Anti-PRMT8 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Epigenetics & Nuclear Function, Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology, Histones Gene Symbol: PRMT8, HRMT1L3, HRMT1L4 UniProt Number: Q9NR22
View Products on Sigmaaldrich.com
ABS517
100 µg  
Recuperando precio...
No pudo obtenerse el precio
La cantidad mínima tiene que ser múltiplo de
Maximum Quantity is
Al finalizar el pedido Más información
Ahorró ()
 
—
Solicitar precio
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      Ofertas especiales

       

      Póngase en contacto con el Servicio de Atención al Cliente

      Descripción

      Replacement Information

      Ofertas especiales

      100% Performance Guaranteed

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS517
      DescriptionAnti-PRMT8 Antibody
      Alternate Names
      • Protein arginine N-methyltransferase 8
      • Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4
      • Protein arginine methyltransferase 8
      Background InformationAsymmetric dimethylation of arginine side chains in proteins is a frequent posttranslational modification, catalyzed by type I protein arginine methyltransferases (PRMTs). PRMT8 is a membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). PRMT8 can form dimers with PRMT2 or PRMT1 and interacts with FYN kinase. PRMT8 is brain specific and it is a vertebrate restricted paralogue of PRMT1. In the past, arginine methylation was mainly observed on abundant proteins such as RNA-binding proteins and histones, but recent advances have revealed a plethora of arginine-methylated proteins implicated in a variety of cellular processes including signal transduction, epigenetic regulation and DNA repair pathways. PRMT8 has been shown to be critical for proper neuronal development and its expression is regionally restricted in the adult suggesting that PRMT8 is chiefly involved in the somatosensory and limbic systems, and a part of the motor nervous system development and maintenance.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-PRMT8 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of PRMT8.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected PRMT8 in human and mouse brain tissuse, and mouse thalamus.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the SAM-dependent methyltransferase PRMT-type domain of Human PRMT8.
      EpitopeC-terminal region of SAM-dependent methyltransferase PRMT-type domain
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman. Predicted to react with Canine, Bovine, Porcine, Chicken, Baboon based on 100% sequence homology. Other homologies: Homology: predicted to react with rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PRMT8
      • HRMT1L3
      • HRMT1L4
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~48 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting using human fetal brain tissue lysate.

      Western Blotting Analysis: 0.1 µg/mL of this antibody detected PRMT8 in 10 µg of human fetal brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      ABS517 04053252983726

      Documentation

      Anti-PRMT8 Antibody Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-PRMT8 Antibody Certificados de análisis

      CargoNúmero de lote
      Anti-PRMT8 - Q2443134 Q2443134
      Anti-PRMT8 - 3460496 3460496
      Anti-PRMT8 - 3541430 3541430
      Anti-PRMT8 - 3713335 3713335
      Anti-PRMT8 - 3851160 3851160
      Anti-PRMT8 - 3910142 3910142
      Anti-PRMT8 - 3994025 3994025
      Anti-PRMT8 -2813497 2813497
      Anti-PRMT8 Polyclonal Antibody 3090557
      Anti-PRMT8 Polyclonal Antibody 2887488
      Show more