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07-100 Anti-Nckβ Antibody

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07-100
200 µg  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-100
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Nckβ Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Nckβ Antibody is validated for use in IP, WB for the detection of Nckβ.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 175-190 of murine Nckβ (EAPSFLSLRRGTALSN)
      HostRabbit
      SpecificityNckβ
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
      Gene Symbol
      • NCK2
      • NCKbeta
      • NCKBETA
      • GRB4
      • Nck-2
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O43639 # Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates.
      SIZE: 380 amino acids; 42915 Da
      SUBUNIT: Interacts with DOCK1, PINCH and TGFB1I1.
      SUBCELLULAR LOCATION: Cytoplasm.
      TISSUE SPECIFICITY: Ubiquitous.
      SIMILARITY: SwissProt: O43639 ## Contains 1 SH2 domain. & Contains 3 SH3 domains.
      Molecular Weight47kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates of murine testes and spleen homogenates
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      07-100 04053252279461

      Documentation

      Anti-Nckβ Antibody Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-Nckβ Antibody Certificados de análisis

      CargoNúmero de lote
      Anti-NckB (rabbit polyclonal IgG) 2905317
      Anti-Nckb (rabbit polyclonal IgG) - 2042216 2042216
      Anti-Nckb (rabbit polyclonal IgG) - 2280861 2280861
      Anti-Nckb - 2023284 2023284
      Anti-Nckbeta; - 20091 20091
      Anti-Nckbeta; - 29624 29624
      Anti-Nckβ - 3189730 3189730
      Anti-Nckβ - 3385687 3385687
      Anti-Nckβ -2616227 2616227
      Anti-Nckβ -2714492 2714492

      Referencias bibliográficas

      Visión general referenciasAplicación Pub Med ID
      Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.
      Oser, M; Mader, CC; Gil-Henn, H; Magalhaes, M; Bravo-Cordero, JJ; Koleske, AJ; Condeelis, J
      Journal of cell science  123  3662-73  2009

      Mostrar resumen Artículo Texto completo
      20971703 20971703
      Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling
      Ling, P., et al
      J Biol Chem, 276:18908-14 (2001)  2001

      Immunoblotting (Western)11279207 11279207