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MABN1851-100UG Anti-Nav1.4 Na+ channel Antibody, clone N255_38

Anti-Nav1.4 Na+ channel, clone N255/38, Cat. No. MABN1851, is a mouse monoclonal antibody that targets Sodium channel protein type 4 subunit alpha (Nav1.4) and has been tested for use in Immunohistochemistry (Paraffin).

MABN1851-100UG
100 μg  
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      Descripción

      Replacement Information
      Description
      Catalogue NumberMABN1851-100UG
      DescriptionAnti-Nav1.4 Na+ channel Antibody, clone N255_38
      Alternate Names
      • Sodium channel protein type 4 subunit alpha
      • Mu-1
      • SkM1
      • Sodium channel protein skeletal muscle subunit alpha
      • Sodium channel protein type IV subunit alpha
      • Voltage-gated sodium channel subunit alpha Nav1.4
      Background InformationSodium channel protein type 4 subunit alpha (UniProt: P15390; also known as Mu-1, SkM1, Sodium channel protein skeletal muscle subunit alpha, Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4) is encoded by the Scn4a gene (Gene ID: 25722) in rat. Nav1.4 is a multi-pass membrane protein that is a component of a voltage-sensitive sodium channel complex, which consists of a pore-forming alpha subunit and one or more regulatory beta subunits. This pore-forming subunit allows Na+ ions to pass in accordance with their electrochemical gradient. It is shown to be essential for normal muscle fiber excitability and for normal muscle contraction and relaxation cycles. It also maintains constant muscle strength in the presence of fluctuating K+ levels. It alternates between resting, activated, and inactivated states. Its channel activity is regulated by the ancillary beta that enhances the presence of the pore-forming alpha subunit at the cell surface. Its interaction with beta subunit is required for rapid channel inactivation and rapid recovery after inactivation and prevents decrease of channel activity in response to repetitive, high-frequency depolarizations. Nav1.4 channel activity is inhibited by tetrodotoxin. Nav1.4 undergoes phosphorylation at serine 1321 by protein kinase C in a highly conserved cytoplasmic loop that leads to inactivation of the sodium channel and reduces peak sodium currents. It contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segment S4 is suggested to be the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. (Ref.: Webb, J., et al. (2009). Pflugers Arch. 457(6); 1253-1263).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Nav1.4 Na+ channel, clone N255/38, Cat. No. MABN1851, is a mouse monoclonal antibody that targets Sodium channel protein type 4 subunit alpha (Nav1.4) and has been tested for use in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:50 dilution from a representative lot detected Nav1.4 Na+ channel in rat cerebral cortex tissue sections.
      Biological Information
      ImmunogenRecombinant fragment corresponding to 118 amino acids from the N-terminal half of Rat Voltage-gated sodium channel subunit alpha (Nav1.4).
      CloneN255/38
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone N255/38 is a mouse monoclonal antibody that targets Sodium channel protein type 4 subunit alpha (Nav1.4). It targets an epitope within the N-terminal, extracellular domain.
      IsotypeIgG2aκ
      Species Reactivity
      • Rat
      Species Reactivity NoteRat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Scn4a
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight208.8 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in rat hippocampus tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected Nav1.4 Na+ channel in rat hippocampus tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABN1851-100UG 04061841276654