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MABN1869-100UG Anti-NMDAR2C Antibody, clone N422/18

Anti-NMDAR2C, clone N422/18, Cat. No. MABN1869, is a highly specific mouse monoclonal antibody that targets Glutamate receptor ionotropic, NMDA 2C and has been tested for use in Western Blotting.

MABN1869-100UG
100 μg  
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      Descripción

      Replacement Information
      Description
      Catalogue NumberMABN1869-100UG
      DescriptionAnti-NMDAR2C Antibody, clone N422/18
      Alternate Names
      • Glutamate receptor ionotropic+C6 NMDA 2C
      • GluN2C
      • Glutamate [NMDA] receptor subunit epsilon-3
      • N-methyl D-aspartate receptor subtype 2C
      • NR2C
      Background InformationGlutamate receptor ionotropic, NMDA 2C (UniProt: Q00961; also known as GluN2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C) is encoded by the Grin2c gene (Gene ID: 24411) in rat. NMDA receptor complexes are ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. They are involved in long-term potentiation and neuronal plasticity and regulate the number of nerve cells during development. However, over-stimulation NMDA receptors can lead to neuronal degeneration. The NMDA receptor complex is permeable to Na+, K+, and Ca2+ in a voltage dependent manner. NMDAR2C is a multi-pass membrane protein that is synthesized with a signal peptide (aa 1-19), which is subsequently cleave off to produce the mature form. NMDAR2C is present as a heterotetramer composed of two zeta subunits (GRIN1) and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIND). Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-NMDAR2C, clone N422/18, Cat. No. MABN1869, is a highly specific mouse monoclonal antibody that targets Glutamate receptor ionotropic, NMDA 2C and has been tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant fragment corresponding to 398 amino acids from the C-terminal, cytoplasmic domain of rat Glutamate receptor ionotropic, NMDAR2C.
      Epitopecytoplasmic domain
      CloneN422/18
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone N422/18 is a mouse monoclonal antibody that specifically detects rat Glutamate receptor ionotropic, NMDAR2C. It targets an epitope within the C-terminal cytoplasmic domain.
      IsotypeIgG1κ
      Species Reactivity
      • Rat
      Species Reactivity NoteRat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Grin2c
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~150 kDa observed; 135.27 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain membrane preparations.

      Western Blotting Analysis: 1 µg/mL of this antibody detected NMDAR2C in rat brain membrane preparations.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABN1869-100UG 04061841038863