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MABT530-AF488 Anti-N-cadherin Antibody, CT Antibody, clone 6A9.2 Antibody, Alexa Fluor® 488 Conjugate

This mouse monoclonal Anti-N-cadherin, CT Antibody, clone 6A9.2, Alexa Fluor® 488 Conjugate, Cat. No. MABT530-AF488 is tested in Immunocytochemistry for the detection of N-Cadherin.

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Research Category: Cell Structure Gene Symbol: CHD2, CDHN, NCAD UniProt Number: P19022
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MABT530-AF488
100 µL  
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      Descripción

      Replacement Information

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RICCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue NumberMABT530-AF488
      DescriptionAnti-N-cadherin Antibody, CT Antibody, clone 6A9.2 Antibody, Alexa Fluor® 488 Conjugate
      Alternate Names
      • CD325
      • CDw325
      • cadherin-2
      • Neural cadherin
      Background InformationCadherin-2 (UniProt P19022; also known as CD325, CDw325, N-cadherin, Neural cadherin) is encoded by the CDH2 (also known as CDHN, NCAD) gene (Gene ID 1000) in human. N-Cadherin is a single-pass type I membrane protein that plays a role in calcium-dependent cell adhesion. N-cadherins preferentially interacts with themselves in a homophilic manner in connecting cells; may thus contribute to the sorting of heterogeneous cell types. Cadherins are synthesized as precursor proteins that are proteolytically cleaved to generate functional, mature proteins. Newly synthesized proN-cadherin (a.a. 1-906) is phosphorylated and proteolytically processed prior to transport to the plasma membrane. Cadherins are composed of an extracellular domain (a.a. 160-724 of human N-cadherin) with five homologous repeats that mediates adhesion, a single pass transmembrane domain (a.a. 725-745 of human N-cadherin), and a conserved cytoplasmic domain (a.a. 746-906 of human N-cadherin) that interacts with catenins to link cadherins to the actin cytoskeleton. N-cadherin is well expressed in endothelial cells and plays an essential role in the maturation and stabilization of normal vessels. However, it also promotes tumor cell survival, migration and invasion, and a high level of its expression is often associated with poor prognosis.
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified mouse monoclonal antibody IgG2a in PBS with 1.5% BSA and 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis mouse monoclonal Anti-N-cadherin, CT Antibody, clone 6A9.2, Alexa Fluor® 488 Conjugate, Cat. No. MABT530-AF488 is tested in Immunocytochemistry for the detection of N-Cadherin.
      Key Applications
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:100 dilution from a representative lot detected N-Cadherin in HeLa cells.

      The unconjugated antibody (Cat. No. MABT530) is shown to be suitable also for Western blotting and Immunohistochemistry (Paraffin) applications.
      Biological Information
      ImmunogenGST/His-tagged recombinant fragment corresponding to 79 amino acids from the N-terminal half of human cadherin-2.
      Clone6A9.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 6A9.2 specifically detects N-cadherin extracellular cadherin 1 domain. It targets an epitope with in a sequence of 79 amino acids in the N-terminal region.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteHuman, Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CHD2
      • CDHN
      • NCAD
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight99.81 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in A431 cells.

      Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected N-Cadherin in A431 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABT530-AF488 04054839169632