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MABC552 Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1

This Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Kallikrein-1/KLK1.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: KLK1 UniProt Number: P06870
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MABC552
100 μg  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC552
      Description Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1
      Alternate Names
      • Kallikrein-1
      • Kidney/pancreas/salivary gland kallikrein
      • Tissue kallikrein
      • Kallikrein-1/KLK1
      Background InformationKallikrein-1 (EC:3.4.21.35; UniProt P06870; also known as Glandular kallikrein 1, hK1, Kallikrein serine protease 1, Kidney/pancreas/salivary gland kallikrein, Renal/pancreas/salivary kallikrein 1, Tissue kallikrein) is encoded by the KLK1 (also known as KLKR) gene (Gene ID 3816) in human. Kallikrein-1 is a member of the kallikrein subfamily of serine proteases, members of which are involved in diverse physiological functions and many are used clinically as biomarkers for cancer. Kallikrein-1 is initially produced as a preproprotein with a signal (aa 1-18) and a propeptide (aa 19-24), cleavage of which releases the mature protein (aa 25-262). Kallikrein-1 is the major kallikrein expressed in the kidney, where it generates kinins (e.g. lysyl-bradykinin and bradykinin) and plays role in kidney function and blood pressure regulation through vasodilatory and natriuretic effects. Decreased kidney Kallikrein-1 level is reported in experimental settings of hypertension, diabetic nephropathy, high salt- and aminoglycoside-induced kidney injury.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Kallikrein-1/KLK1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein-1/KLK1 in human pancreas and human colon tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminal half of human Kallikrein-1/KLK1.
      EpitopeC-terminal half
      Clone11C7.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both spliced isoforms.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KLK1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~30 kDa observed. 28.9 kDa/isoform 1 and 23.8 kDa/isoform 2 calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human salivary gland tissue lysate.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected Kallikrein-1/KLK1 in 10 µg of human salivary gland tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABC552 04055977276978

      Documentation

      Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1 Certificados de análisis

      CargoNúmero de lote
      Anti-Kallikrein-1/KLK1, clone 11C7.1 -Q2595856 Q2595856

      Licencias necesarias e Información técnica

      Cargo
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      White Paper: Further considerations of antibody validation and usage.