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MABF231 Anti-IL1RL1, clone RMST2-2, Azide Free Antibody

Anti-IL1RL1 antibody, clone RMST2-2, Azide Free is an antibody against IL1RL1 for use in flow cytometry & activity assay.

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Il1rl1, Ly84, St2, Ste2 UniProt Number: P14719
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MABF231
100 µL  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, ACTRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF231
      DescriptionAnti-IL1RL1, clone RMST2-2, Azide Free Antibody
      Alternate Names
      • Interleukin-1 receptor-like 1
      • Lymphocyte antigen 84
      • Protein ST2
      • Protein T1
      Background InformationIL1RL1, or Interleukin-1 receptor-like 1 protein, which is also known as Lymphocyte antigen 84, Protein ST2, or Protein T1, and encoded by the gene IL1rL1/Ly84/St2/Ste2 is the receptor for IL-33 and its activation recruits MYD88, IRAK1, IRAK4 and TRAF6 transcription factors and promotes the activation of ERK1/MAPK14 and MAPK8. IL1RL1 also is involved in T-helper Cell activation and function. IL1RL1 is localized to the plasma membrane. IL1RL1 is expressed in hematopoietic tissues, macrophages, epithelial and fibroblast cells lines as well as important tissues such as heart and lung. IL1RL1 is a member of the Toll-like receptor superfamily and interestingly plays an important role not in inflammation but in cardiac protection. When IL-33 binds it elicits a cardioprotective signaling response in the tissue and thus helps protect the heart tissue during times of ischemia for instance. Defects in IL1RL1 have been linked to atopic dermatitis and asthma.
      References
      Product Information
      FormatPurified
      PresentationPBS without preservatives
      Quality LevelMQ100
      Applications
      ApplicationAnti-IL1RL1 antibody, clone RMST2-2, Azide Free is an antibody against IL1RL1 for use in flow cytometry & activity assay.
      Key Applications
      • Flow Cytometry
      • Activity Assay
      Application NotesActivity Assay Analysis: A representative lot from an independent laboratory induces IL-6 production in BMCC cells (Prof. Hisaya Akiba, Jutendo University).
      Biological Information
      ImmunogenMouse ST-2/IL1RL1.
      CloneRMST2-2
      HostRat
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Il1rl1
      • Ly84
      • St2
      • Ste2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight64 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvalauted by Flow Cytometry in ST2/L5178Y and L5178Y parent cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected IL1RL1 in 1X10E6 ST2/L5178Y cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABF231 04053252946943

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies