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MABS1301 Anti-IGF-IRα subunit Antibody, clone 1B1

This Anti-IGF-IRα subunit Antibody, clone 1B1 is validated for use in Flow Cytometry, Immunocytochemistry, Western Blotting for the detection of IGF-IRα subunit.

Anti-IGF-IRα subunit Antibody, clone 1B1 : Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: IGF1R, CD221, IGFIR, IGFR, JTK13 UniProt Number: P08069
MABS1301
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, ICC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1301
      DescriptionAnti-IGF-IRα subunit Antibody, clone 1B1
      Alternate Names
      • Insulin-like growth factor 1 receptor
      • CD221
      • IGF-I receptor
      • Insulin-like growth factor I receptor
      • Insulin-like growth factor 1 receptor alpha chain
      • Insulin-like growth factor 1 receptor beta chain
      • IGF-IRα subunit
      Background InformationInsulin-like growth factor 1 receptor (EC:2.7.10.1; UniProt P08069; also known as CD221, IGF-I receptor, Insulin-like growth factor I receptor) is encoded by the IGF1R (also known as CD221, IGFIR, IGFR, JTK13) gene (Gene ID 3480) in human. The insulin-like growth factor 1 (IGF-1) receptor is a receptor tyrosine kinase activated by IGF-1 and IGF-2. IGF-1 receptor is initially produced as a precursor protein with a signal peptide sequence (aa 1-30). Post-translational cleavages produce one extracellular alpha (aa 31-736) chain and one transmembrane beta chain (aa 741 – 1367) linked together by a disulfide bond. Two sets of alpha-beta dimers then form the functional tetrameric receptor complex via a disulfide linkage between their alpha chain. Upon ligand binding, the alpha chains induce the tyrosine autophosphorylation of the beta chains, which in turn trigger cell type-specific downstream signaling cascade of events.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-IGF-IRα subunit Antibody, clone 1B1 is validated for use in Flow Cytometry, Immunocytochemistry, Western Blotting for the detection of IGF-IRα subunit.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      • Western Blotting
      Application NotesFlow Cytometry Analysis: A representative lot detected IGF-I receptor on the surface of MCF-7 human breast cancer cells (Nakadate, Y., et al. (2014). Monoclon. Antib. Immunodiagn. Immunother. 33(2):126-128).
      Immunocytochemistry Analysis: A representative lot detected IGF-I receptor on the surface of MCF-7 human breast cancer cells (Nakadate, Y., et al. (2014). Monoclon. Antib. Immunodiagn. Immunother. 33(2):126-128).
      Western Blotting Analysis: A representative lot detected the extracellular alpha (aa 31-736) chain of IGF-1R in MCF-7 cell extracts (Nakadate, Y., et al. (2014). Monoclon. Antib. Immunodiagn. Immunother. 33(2):126-128).
      Biological Information
      ImmunogenRecombinant protein corresponding to the extracellular fragment of human IGF-IR precursor protein.
      EpitopeIGF-IR extracellular alpha chain.
      Clone1B1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 1B1 detected a band corresponding to the size of the alpha subunit of IGF-1R by immunoblotting analysis of recombinant protein and MCF-7 cell extracts (Nakadate, Y., et al. (2014). Monoclon. Antib. Immunodiagn. Immunother. 33(2):126-128).
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IGF1R
      • CD221
      • IGFIR
      • IGFR
      • JTK13
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight80.41 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in MCF7 cells.

      Flow Cytometry Analysis: 0.1 µg of this antibody detected IGF-IRα subunit on MCF7 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABS1301 04055977314991

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies