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ABC488 Anti-Gumby Antibody

Anti-Gumby Antibody is an antibody against Gumby for use in Western Blotting.

Anti-Gumby Antibody : Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: OTULIN, FAM105B UniProt Number: Q96BN8
ABC488
100 µL  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC488
      DescriptionAnti-Gumby Antibody
      Alternate Names
      • Ubiquitin thioesterase otulin
      • Deubiquitinating enzyme otulin
      • OTU domain-containing deubiquitinase with linear linkage specificity
      • Ubiquitin thioesterase Gumby
      • Gumby
      Background InformationUbiquitin thioesterase otulin (EC:3.4.19.12; UniProt Q96BN8), also known as Deubiquitinating enzyme otulin, Gumby, OTU domain-containing deubiquitinase with linear linkage specificity, Protein FAM105B, Ubiquitin thioesterase Gumby), is encoded by the OTULIN gene in murine species. Gumby belongs to the ovarian tumour (OTU) domain-containing protease family of deubiquitinases (DUBs) that catalyze the removal of ubiquitins from ubiquitinated proteins. Gumby is reported to associate with linear ubiquitin assembly complex (LUBAC) and counteract LUBAC activity by removing linear ('Met-1'-linked) polyubiquitin chains from substrate proteins. The gumby–LUBAC axis plays an important role in angiogenesis, craniofacial and neuronal development by regulating canonical Wnt signalling.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-Gumby Antibody is an antibody against Gumby for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Gumby.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OTULIN
      • FAM105B
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~55 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in U2OS cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Gumby in 10 µg of U2OS cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      ABC488 04055977169072