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MAB1087 Anti-Eosinophil Peroxidase Antibody, clone AHE-1

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MAB1087
100 µL  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB1087
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Eosinophil Peroxidase Antibody, clone AHE-1
      References
      Product Information
      FormatAscites
      PresentationAscites fluid.
      Quality LevelMQ100
      Applications
      ApplicationDetect Eosinophil Peroxidase using this Anti-Eosinophil Peroxidase Antibody, clone AHE-1 validated for use in IC.
      Key Applications
      • Immunocytochemistry
      Application NotesFinal working dilutions must be determined by end user.
      Biological Information
      CloneAHE-1
      HostMouse
      SpecificityReacts specifically with human eosinophil peroxidase from eosinophils among peripheral blood cells. Eosinophil peroxidase is felt to play an important role in eosinophil function and perhaps endothelial injury in hypereosinophilic states.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • EPX
      • EPO
      • EPX-PEN
      • EPER
      • EPP
      • EC 1.11.1.7 [Contains: Eosinophil peroxidase light chain
      • Eosinophil peroxidase heavy chain].
      UniProt Number
      UniProt SummaryCOFACTOR: Binds 1 calcium ion per heterodimer (By similarity). & Binds 1 heme B (iron-protoporphyrin IX) covalently through ester linkages to hydroxylated methyl groups formed auto- catalytically with hydrogen peroxide at the heme C-1 and C-5 positions. The ester linkage to Asp-232 was observed in 30% of the chains.
      SIZE: 715 amino acids; 81040 Da
      SUBUNIT: Tetramer of two light chains and two heavy chains.
      SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.
      DISEASE: SwissProt: P11678 # Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining.
      SIMILARITY: SwissProt: P11678 ## Belongs to the peroxidase family. XPO subfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MAB1087 04053252316098

      Documentation

      Anti-Eosinophil Peroxidase Antibody, clone AHE-1 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-Eosinophil Peroxidase Antibody, clone AHE-1 Certificados de análisis

      CargoNúmero de lote
      MOUSE ANTI-EOSINOPHIL PEROXIDASE 2477410
      MOUSE ANTI-EOSINOPHIL PEROXIDASE MONOCLONAL ANTIBODY - 2272685 2272685
      MOUSE ANTI-EOSINOPHIL PEROXIDASE MONOCLONAL ANTIBODY - 2395693 2395693
      MOUSE ANTI-EOSINOPHIL PEROXIDASE - 3254581 3254581
      MOUSE ANTI-EOSINOPHIL PEROXIDASE - 3780649 3780649
      MOUSE ANTI-EOSINOPHIL PEROXIDASE - 4076678 4076678
      MOUSE ANTI-EOSINOPHIL PEROXIDASE - 4202320 4202320
      MOUSE ANTI-EOSINOPHIL PEROXIDASE - 4224971 4224971
      MOUSE ANTI-EOSINOPHIL PEROXIDASE -2651925 2651925
      MOUSE ANTI-EOSINOPHIL PEROXIDASE -2835741 2835741

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Bilateral increase in expression and concentration of tachykinin in a unilateral rabbit muscle overuse model that leads to myositis.
      Song, Y; Stål, PS; Yu, JG; Forsgren, S
      BMC musculoskeletal disorders  14  134  2013

      Mostrar resumen
      23587295 23587295
      Marked Effects of Tachykinin in Myositis Both in the Experimental Side and Contralaterally: Studies on NK-1 Receptor Expressions in an Animal Model.
      Song, Y; Stål, PS; Yu, J; Forsgren, S
      ISRN inflammation  2013  907821  2013

      Mostrar resumen
      24049666 24049666
      Effects on contralateral muscles after unilateral electrical muscle stimulation and exercise.
      Song, Y; Forsgren, S; Yu, J; Lorentzon, R; Stål, PS
      PloS one  7  e52230  2011

      Mostrar resumen
      23284946 23284946
      VGluT2 and NMDAR1 Expression in Cells in the Inflammatory Infiltrates in Experimentally Induced Myositis: Evidence of Local Glutamate Signaling Suggests Autocrine/Paracrine Effects in an Overuse Injury Model.
      Christoph Spang,Alexander Scott,Patrik Danielson,Ronny Lorentzon,Sture Forsgren
      Inflammation  35  2011

      Mostrar resumen
      21193952 21193952
      Neutrophilic cell production by combination of stem cell factor and thrombopoietin from CD34(+) cord blood cells in long-term serum-deprived liquid culture.
      N Sawai, K Koike, S Ito, H H Mwamtemi, Y Kurokawa, T Kinoshita, K Sakashita, T Higuchi, K Takeuchi, M Shiohara, H Miyazaki, T Kato, A Komiyama
      Blood  93  509-18  1998

      Mostrar resumen
      9885212 9885212
      Establishment of a GM-CSF-dependent megakaryoblastic cell line with the potential to differentiate into an eosinophilic lineage in response to retinoic acids.
      F Ma, K Koike, T Higuchi, T Kinoshita, K Takeuchi, H H Mwamtemi, N Sawai, T Kamijo, M Shiohara, S Horie, S Kawa, Y Sasaki, E Hidaka, O Yamagami, T Yamashita, T Koike, E Ishii, A Komiyama, F Ma, K Koike, T Higuchi, T Kinoshita, K Takeuchi, H H Mwamtemi, N Sawai, T Kamijo, M Shiohara, S Horie, S Kawa, Y Sasaki, E Hidaka, O Yamagami, T Yamashita, T Koike, E Ishii, A Komiyama
      British journal of haematology  100  427-35  1998

      Mostrar resumen
      9488639 9488639
      Preparation and characterization of a monoclonal antibody that inhibits human neutrophil elastase activity.
      Skubitz, K M, et al.
      J. Leukoc. Biol., 44: 158-65 (1988)  1987

      Mostrar resumen
      3411232 3411232