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ABN40 Anti-DLK1 Antibody

This Anti-DLK1 Antibody is validated for use in WB, IH for the detection of DLK1.

Anti-DLK1 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: DLK1, DLK UniProt Number: P80370
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ABN40
100 µg  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN40
      DescriptionAnti-DLK1 Antibody
      Alternate Names
      • Protein delta homolog 1
      • DLK-1
      • pG2
      • Fetal antigen 1
      • FA1
      Background InformationDelta-like 1 homolog (DLK1), also known as fetal antigen 1 (FA1) and preadipocyte factor 1 (pref-1), is a transmembrane protein containing 6 epidermal growth factor repeats whose expression is known to modulate differentiation signals. Studies have shown DLK1 is involved in differentiation of several cell types, including adipocytes. Studies have shown deficiencies in DLK1 displaying growth retardation, obesity, skeletal malformation, and increased serum lipid. DLK1 is a paternally expressed imprinted gene that plays a role in normal development and in the maintence of homeostatsis of adipose tissue mass.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HepG2 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-DLK1 Antibody is validated for use in WB, IH for the detection of DLK1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected DLK1 in mouse embryonic tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human DLK1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010].
      Gene Symbol
      • DLK1
      • DLK
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummarySUBUNIT STRUCTURE: Monomer.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICITY: Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue.

      PTM: N- and O-glycosylated.

      SEQUENCE SIMILARITIES: Contains 6 EGF-like domains.

      SEQUENCE CAUTION: The sequence CAA35582.1 differs from that shown. Reason: Frameshift at positions 22, 108 and 199.
      Molecular Weight~47 kDa observed. The calculated molecular weight of this protein is 41 kDa, but can be observed at ~41-55 kDa due to high glycosylation.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HepG2 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected DLK1 on 10 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      ABN40 04053252536595

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-DLK1 Antibody Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-DLK1 Antibody Certificados de análisis

      CargoNúmero de lote
      Anti-DLK1 -
      Anti-DLK1 - 2395815 2395815
      Anti-DLK1 - 2007344 2007344
      Anti-DLK1 - 2055304 2055304
      Anti-DLK1 - 2197299 2197299
      Anti-DLK1 - 2272705 2272705
      Anti-DLK1 - 2292191 2292191
      Anti-DLK1 - 2318817 2318817
      Anti-DLK1 - 3277590 3277590
      Anti-DLK1 - 3698174 3698174
      Show more

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      MABN671 Anti-DLK1 Antibody, clone 3A10 Precios y disponibilidad

      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies