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MAB2015 Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4

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MAB2015
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Ca, Ch, H, Po, Rb, ShELISA, RIA, WB, IHCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB2015
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cartilage Proteoglycan Antibody, adult, clone EFG-4
      References
      Product Information
      FormatAscites
      PresentationAscites fluid
      Quality LevelMQ100
      Applications
      ApplicationAnti-Cartilage Proteoglycan Antibody, adult, clone EFG-4 detects level of Cartilage Proteoglycan & has been published & validated for use in ELISA, RIA, WB, IH.
      Key Applications
      • ELISA
      • Radioimmunoassay
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern blot: 1:1,00 - 1:200
      Immunohistochemistry: 1:50 - 250
      ELISA: 1:250 - 1: 2500
      RIA: 1:20,000 - 1:40,000
      Optimal working dilutions must be determined by the end user.I/
      Biological Information
      ImmunogenHuman adult cartilage proteoglycan.
      Epitopeadult
      CloneEFG-4
      HostMouse
      SpecificityRecognizes the short peptides substituted with keratan sulfate side chains and within the core protein of proteoglycans in articular cartilages, chicken limb bud and cornea. Does not cross-react with human fetal cartilage proteoglycans.
      IsotypeIgG1κ
      Species Reactivity
      • Bovine
      • Canine
      • Chicken
      • Human
      • Pig
      • Rabbit
      • Sheep
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
      Gene Symbol
      • ACAN
      • MSK16
      • SEDK
      • CSPCP
      • AGCAN
      • AGC1
      • CSPG1
      • CSPGCP
      Non-Reactive Species
      • Mouse
      • Rat
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16112 # This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
      SIZE: 2415 amino acids; 250193 Da
      SUBUNIT: Interacts with FBLN1 (By similarity).
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
      TISSUE SPECIFICITY: Restricted to cartilages.
      DEVELOPMENTAL STAGE: Expression was detected in chondrocytes throughout the developing skeleton.
      DOMAIN: SwissProt: P16112 Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.
      PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.
      DISEASE: SwissProt: P16112 # Defects in AGC1 are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.
      SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 1 EGF-like domain. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 4 Link domains. & Contains 1 Sushi (CCP/SCR) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MAB2015 08436037126369

      Documentation

      Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4 Certificados de análisis

      CargoNúmero de lote
      Anti-Rabbit Light Chain Specific Cy5 Conjugated - NG1614458 NG1614458
      MOUSE ANTI- HUMAN CARTILAGE PROTEOGLYCAN (ADULT) MONOCLONAL ANTIBODY - 2392212 2392212
      MOUSE ANTI- HUMAN CARTILAGE PROTEOGLYCAN (ADULT) - 3195402 3195402
      MOUSE ANTI- HUMAN CARTILAGE PROTEOGLYCAN (ADULT) - 3527758 3527758
      MOUSE ANTI- HUMAN CARTILAGE PROTEOGLYCAN (ADULT) - 3880392 3880392
      MOUSE ANTI- HUMAN CARTILAGE PROTEOGLYCAN (ADULT) -2529862 2529862
      MOUSE ANTI- HUMAN CARTILAGE PROTEOGLYCAN (ADULT) -2601702 2601702
      MOUSE ANTI- HUMAN CARTILAGE PROTEOGLYCAN (ADULT) MONOCLONAL ANTIBODY 2961745
      MOUSE ANTI- HUMAN CARTILAGE PROTEOGLYCAN (ADULT) MONOCLONAL ANTIBODY 3084140
      MOUSE ANTI- HUMAN CARTILAGE PROTEOGLYCAN (ADULT) MONOCLONAL ANTIBODY 2465112

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes.
      Shakibaei, M; Allaway, D; Nebrich, S; Mobasheri, A
      Evidence-based complementary and alternative medicine : eCAM  2012  509383  2011

      Mostrar resumen
      22474508 22474508
      IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.
      Montaseri, A; Busch, F; Mobasheri, A; Buhrmann, C; Aldinger, C; Rad, JS; Shakibaei, M
      PloS one  6  e28663  2010

      Mostrar resumen Artículo Texto completo
      22194879 22194879
      Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment.
      Buhrmann, C; Mobasheri, A; Matis, U; Shakibaei, M
      Arthritis research & therapy  12  R127  2009

      Mostrar resumen
      20594343 20594343
      Cell-laden and cell-free biopolymer hydrogel for the treatment of osteochondral defects in a sheep model.
      Jan C Schagemann,Christoph Erggelet,Hsi-Wei Chung,Andreas Lahm,Haymo Kurz,Eike H Mrosek
      Tissue engineering. Part A  15  2009

      Mostrar resumen
      18783325 18783325
      Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cells: a biochemical, morphological and ultrastructural study.
      C Csaki,U Matis,A Mobasheri,H Ye,M Shakibaei
      Histochemistry and cell biology  128  2007

      Mostrar resumen
      17922135 17922135
      Experimental studies on the effects of recombinant human matrix metalloproteinases on herniated disc tissues--how to facilitate the natural resorption process of herniated discs.
      Hirotaka Haro, Hiromichi Komori, Tsuyoshi Kato, Yasushi Hara, Masahiro Tagawa, Kenichi Shinomiya, Dan M Spengler
      Journal of orthopaedic research : official publication of the Orthopaedic Research Society  23  412-9  2004

      Mostrar resumen
      15734256 15734256
      Immunological studies of sheep brain keratan sulphate proteoglycans.
      Nickoletta Papageorgakopoulou, Achilleas D Theocharis, Spyros S Skandalis, Demitrios H Vynios, Dimitrios A Theocharis, Constantine P Tsiganos
      Biochimie  84  1225-8  2002

      Mostrar resumen
      12628299 12628299
      Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage.
      Cs-Szabó, G, et al.
      Arthritis Rheum., 38: 660-8 (1995)  1994

      Mostrar resumen
      7538297 7538297
      Chondrons from articular cartilage. (IV). Immunolocalization of proteoglycan epitopes in isolated canine tibial chondrons.
      Poole, C A, et al.
      J. Histochem. Cytochem., 39: 1175-87 (1991)  1991

      Mostrar resumen
      1717545 1717545
      Proteoglycan-targeted antibodies as markers on non-Hodgkin lymphoma xenografts.
      Kopper, L, et al.
      Cancer Immunol. Immunother., 32: 137-42 (1990)  1990

      Mostrar resumen
      2289206 2289206

      Ficha técnica

      Cargo
      MOUSE ANTI- HUMAN CARTILAGE PROTEOGLYCAN (ADULT)

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies